Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells.

Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells.

Ivermectin is currently approved for treatment of both clinical and veterinary infections by nematodes, including Onchocerca cervicalis in horses and Onchocerca volvulus in humans. However, ivermectin has never been shown to be effective against bacterial pathogens. Here we show that ivermectin also...

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Main Authors: Matthew A Pettengill, Verissa W Lam, Ikechukwu Ollawa, Camila Marques-da-Silva, David M Ojcius
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3484050?pdf=render
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spelling doaj-b8d19e6bccb84a94b4e4dca905ffdcc62020-11-25T02:30:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01710e4845610.1371/journal.pone.0048456Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells.Matthew A PettengillVerissa W LamIkechukwu OllawaCamila Marques-da-SilvaDavid M OjciusIvermectin is currently approved for treatment of both clinical and veterinary infections by nematodes, including Onchocerca cervicalis in horses and Onchocerca volvulus in humans. However, ivermectin has never been shown to be effective against bacterial pathogens. Here we show that ivermectin also inhibits infection of epithelial cells by the bacterial pathogen, Chlamydia trachomatis, at doses that could be envisioned clinically for sexually-transmitted or ocular infections by Chlamydia.http://europepmc.org/articles/PMC3484050?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Matthew A Pettengill
Verissa W Lam
Ikechukwu Ollawa
Camila Marques-da-Silva
David M Ojcius
spellingShingle Matthew A Pettengill
Verissa W Lam
Ikechukwu Ollawa
Camila Marques-da-Silva
David M Ojcius
Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells.
PLoS ONE
author_facet Matthew A Pettengill
Verissa W Lam
Ikechukwu Ollawa
Camila Marques-da-Silva
David M Ojcius
author_sort Matthew A Pettengill
title Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells.
title_short Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells.
title_full Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells.
title_fullStr Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells.
title_full_unstemmed Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells.
title_sort ivermectin inhibits growth of chlamydia trachomatis in epithelial cells.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2012-01-01
description Ivermectin is currently approved for treatment of both clinical and veterinary infections by nematodes, including Onchocerca cervicalis in horses and Onchocerca volvulus in humans. However, ivermectin has never been shown to be effective against bacterial pathogens. Here we show that ivermectin also inhibits infection of epithelial cells by the bacterial pathogen, Chlamydia trachomatis, at doses that could be envisioned clinically for sexually-transmitted or ocular infections by Chlamydia.
url http://europepmc.org/articles/PMC3484050?pdf=render
work_keys_str_mv AT matthewapettengill ivermectininhibitsgrowthofchlamydiatrachomatisinepithelialcells
AT verissawlam ivermectininhibitsgrowthofchlamydiatrachomatisinepithelialcells
AT ikechukwuollawa ivermectininhibitsgrowthofchlamydiatrachomatisinepithelialcells
AT camilamarquesdasilva ivermectininhibitsgrowthofchlamydiatrachomatisinepithelialcells
AT davidmojcius ivermectininhibitsgrowthofchlamydiatrachomatisinepithelialcells
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