LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3

LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3

Abstract Background Acute spinal cord injury (SCI) could cause mainly two types of pathological sequelae, the primary mechanical injury, and the secondary injury. The macrophage in SCI are skewed toward the M1 phenotype that might cause the failure to post-SCI repair. Methods SCI model was establish...

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Bibliographic Details
Main Authors: Jiahui Zhou, Zhiyue Li, Tianding Wu, Qun Zhao, Qiancheng Zhao, Yong Cao
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Neuroinflammation
Subjects:
spinal cord injury (SCI)
Macrophage polarization
lncGBP9
SOCS3
STAT1/STAT6
MiR-34a
Online Access:http://link.springer.com/article/10.1186/s12974-020-01805-5

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http://link.springer.com/article/10.1186/s12974-020-01805-5

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