Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis

Among the symptoms of patients with rheumatoid arthritis (RA), joint stiffness is influenced by diurnal rhythm and reaches peak in the morning, which is a common complaint and reflects the circadian nature of disease manifestation. In addition, inflammatory cytokines, which reach peak secretion earl...

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Main Authors:	Kohsuke Yoshida, Teppei Hashimoto, Yoshitada Sakai, Akira Hashiramoto
Format:	Article
Language:	English
Published:	Hindawi Limited 2014-01-01
Series:	Journal of Immunology Research
Online Access:	http://dx.doi.org/10.1155/2014/282495

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spelling	doaj-b8c9e4b46d55413da0a1a296caa21d082020-11-24T23:48:55ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/282495282495Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid ArthritisKohsuke Yoshida0Teppei Hashimoto1Yoshitada Sakai2Akira Hashiramoto3Faculty of Health Sciences, Kobe University School of Medicine, Kobe 654-0142, JapanDepartment of General Internal Medicine, Kobe University School of Medicine, Kobe 650-0017, JapanDivision of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanFaculty of Health Sciences, Kobe University School of Medicine, Kobe 654-0142, JapanAmong the symptoms of patients with rheumatoid arthritis (RA), joint stiffness is influenced by diurnal rhythm and reaches peak in the morning, which is a common complaint and reflects the circadian nature of disease manifestation. In addition, inflammatory cytokines, which reach peak secretion early in the morning are major players causing the morning stiffness. In this review, we explore the link between the circadian clock and inflammation, focusing on the interactions of various clock genes with the immune-pathways underlying the pathology of rheumatoid arthritis.http://dx.doi.org/10.1155/2014/282495
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kohsuke Yoshida Teppei Hashimoto Yoshitada Sakai Akira Hashiramoto
spellingShingle	Kohsuke Yoshida Teppei Hashimoto Yoshitada Sakai Akira Hashiramoto Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis Journal of Immunology Research
author_facet	Kohsuke Yoshida Teppei Hashimoto Yoshitada Sakai Akira Hashiramoto
author_sort	Kohsuke Yoshida
title	Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis
title_short	Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis
title_full	Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis
title_fullStr	Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis
title_full_unstemmed	Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis
title_sort	involvement of the circadian rhythm and inflammatory cytokines in the pathogenesis of rheumatoid arthritis
publisher	Hindawi Limited
series	Journal of Immunology Research
issn	2314-8861 2314-7156
publishDate	2014-01-01
description	Among the symptoms of patients with rheumatoid arthritis (RA), joint stiffness is influenced by diurnal rhythm and reaches peak in the morning, which is a common complaint and reflects the circadian nature of disease manifestation. In addition, inflammatory cytokines, which reach peak secretion early in the morning are major players causing the morning stiffness. In this review, we explore the link between the circadian clock and inflammation, focusing on the interactions of various clock genes with the immune-pathways underlying the pathology of rheumatoid arthritis.
url	http://dx.doi.org/10.1155/2014/282495
work_keys_str_mv	AT kohsukeyoshida involvementofthecircadianrhythmandinflammatorycytokinesinthepathogenesisofrheumatoidarthritis AT teppeihashimoto involvementofthecircadianrhythmandinflammatorycytokinesinthepathogenesisofrheumatoidarthritis AT yoshitadasakai involvementofthecircadianrhythmandinflammatorycytokinesinthepathogenesisofrheumatoidarthritis AT akirahashiramoto involvementofthecircadianrhythmandinflammatorycytokinesinthepathogenesisofrheumatoidarthritis
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Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis

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