Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis

Among the symptoms of patients with rheumatoid arthritis (RA), joint stiffness is influenced by diurnal rhythm and reaches peak in the morning, which is a common complaint and reflects the circadian nature of disease manifestation. In addition, inflammatory cytokines, which reach peak secretion earl...

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Bibliographic Details
Main Authors: Kohsuke Yoshida, Teppei Hashimoto, Yoshitada Sakai, Akira Hashiramoto
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2014/282495