Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegans

During meiosis, sex chromosomes show silenced gene expression that is disrupted when translocated to autosomes. Here, the authors engineer C. elegans with bisected X chromosomes and see active transcription in gonads, indicating continuity of sex chromosomes promotes silencing.

Bibliographic Details
Main Authors:	Yisrael Rappaport, Hanna Achache, Roni Falk, Omer Murik, Oren Ram, Yonatan B. Tzur
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-24815-0

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spelling	doaj-b8c74cbf8faa449392cb3b9e02e9494e2021-08-15T11:40:43ZengNature Publishing GroupNature Communications2041-17232021-08-0112111510.1038/s41467-021-24815-0Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegansYisrael Rappaport0Hanna Achache1Roni Falk2Omer Murik3Oren Ram4Yonatan B. Tzur5Department of Genetics, The Institute of Life Sciences, The Hebrew University of JerusalemDepartment of Genetics, The Institute of Life Sciences, The Hebrew University of JerusalemDepartment of Genetics, The Institute of Life Sciences, The Hebrew University of JerusalemMedical Genetics Institute, Shaare Zedek Medical CenterDepartment of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of JerusalemDepartment of Genetics, The Institute of Life Sciences, The Hebrew University of JerusalemDuring meiosis, sex chromosomes show silenced gene expression that is disrupted when translocated to autosomes. Here, the authors engineer C. elegans with bisected X chromosomes and see active transcription in gonads, indicating continuity of sex chromosomes promotes silencing.https://doi.org/10.1038/s41467-021-24815-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yisrael Rappaport Hanna Achache Roni Falk Omer Murik Oren Ram Yonatan B. Tzur
spellingShingle	Yisrael Rappaport Hanna Achache Roni Falk Omer Murik Oren Ram Yonatan B. Tzur Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegans Nature Communications
author_facet	Yisrael Rappaport Hanna Achache Roni Falk Omer Murik Oren Ram Yonatan B. Tzur
author_sort	Yisrael Rappaport
title	Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegans
title_short	Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegans
title_full	Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegans
title_fullStr	Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegans
title_full_unstemmed	Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegans
title_sort	bisection of the x chromosome disrupts the initiation of chromosome silencing during meiosis in caenorhabditis elegans
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-08-01
description	During meiosis, sex chromosomes show silenced gene expression that is disrupted when translocated to autosomes. Here, the authors engineer C. elegans with bisected X chromosomes and see active transcription in gonads, indicating continuity of sex chromosomes promotes silencing.
url	https://doi.org/10.1038/s41467-021-24815-0
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Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegans

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