Mitochondrial DNA Damage and Diseases [version 1; referees: 1 approved, 2 approved with reservations]

Mitochondrial DNA Damage and Diseases [version 1; referees: 1 approved, 2 approved with reservations]

Various endogenous and environmental factors can cause mitochondrial DNA (mtDNA) damage.  One of the reasons for enhanced mtDNA damage could be its proximity to the source of oxidants, and lack of histone-like protective proteins. Moreover, mitochondria contain inadequate DNA repair pathways, and, d...

Full description

Bibliographic Details
Main Authors: Gyanesh Singh, U C Pachouri, Devika Chanu Khaidem, Aman Kundu, Chirag Chopra, Pushplata Singh
Format: Article
Language:English
Published: F1000 Research Ltd 2015-07-01
Series:F1000Research
Subjects:
Genomics
Structure: Transcription & Translation
Online Access:http://f1000research.com/articles/4-176/v1
id doaj-b8c2576932334afd9c873c68c5b5b472
record_format Article
spelling doaj-b8c2576932334afd9c873c68c5b5b4722020-11-25T03:06:26ZengF1000 Research LtdF1000Research2046-14022015-07-01410.12688/f1000research.6665.17161Mitochondrial DNA Damage and Diseases [version 1; referees: 1 approved, 2 approved with reservations]Gyanesh Singh0U C Pachouri1Devika Chanu Khaidem2Aman Kundu3Chirag Chopra4Pushplata Singh5School of Biotechnology and Biosciences, Lovely Professional University, Phagwara, Punjab, IndiaSchool of Biotechnology and Biosciences, Lovely Professional University, Phagwara, Punjab, IndiaSchool of Biotechnology and Biosciences, Lovely Professional University, Phagwara, Punjab, IndiaSchool of Biotechnology and Biosciences, Lovely Professional University, Phagwara, Punjab, IndiaSchool of Biotechnology and Biosciences, Lovely Professional University, Phagwara, Punjab, IndiaDepartment of Medicine, Punjab Institute of Medical Sciences, Jalandhar, Punjab, IndiaVarious endogenous and environmental factors can cause mitochondrial DNA (mtDNA) damage.  One of the reasons for enhanced mtDNA damage could be its proximity to the source of oxidants, and lack of histone-like protective proteins. Moreover, mitochondria contain inadequate DNA repair pathways, and, diminished DNA repair capacity may be one of the factors responsible for high mutation frequency of the mtDNA. mtDNA damage might cause impaired mitochondrial function, and, unrepaired mtDNA damage has been frequently linked with several diseases. Exploration of mitochondrial perspective of diseases might lead to a better understanding of several diseases, and will certainly open new avenues for detection, cure, and prevention of ailments.http://f1000research.com/articles/4-176/v1GenomicsStructure: Transcription & Translation
collection DOAJ
language English
format Article
sources DOAJ
author Gyanesh Singh
U C Pachouri
Devika Chanu Khaidem
Aman Kundu
Chirag Chopra
Pushplata Singh
spellingShingle Gyanesh Singh
U C Pachouri
Devika Chanu Khaidem
Aman Kundu
Chirag Chopra
Pushplata Singh
Mitochondrial DNA Damage and Diseases [version 1; referees: 1 approved, 2 approved with reservations]
F1000Research
Genomics
Structure: Transcription & Translation
author_facet Gyanesh Singh
U C Pachouri
Devika Chanu Khaidem
Aman Kundu
Chirag Chopra
Pushplata Singh
author_sort Gyanesh Singh
title Mitochondrial DNA Damage and Diseases [version 1; referees: 1 approved, 2 approved with reservations]
title_short Mitochondrial DNA Damage and Diseases [version 1; referees: 1 approved, 2 approved with reservations]
title_full Mitochondrial DNA Damage and Diseases [version 1; referees: 1 approved, 2 approved with reservations]
title_fullStr Mitochondrial DNA Damage and Diseases [version 1; referees: 1 approved, 2 approved with reservations]
title_full_unstemmed Mitochondrial DNA Damage and Diseases [version 1; referees: 1 approved, 2 approved with reservations]
title_sort mitochondrial dna damage and diseases [version 1; referees: 1 approved, 2 approved with reservations]
publisher F1000 Research Ltd
series F1000Research
issn 2046-1402
publishDate 2015-07-01
description Various endogenous and environmental factors can cause mitochondrial DNA (mtDNA) damage.  One of the reasons for enhanced mtDNA damage could be its proximity to the source of oxidants, and lack of histone-like protective proteins. Moreover, mitochondria contain inadequate DNA repair pathways, and, diminished DNA repair capacity may be one of the factors responsible for high mutation frequency of the mtDNA. mtDNA damage might cause impaired mitochondrial function, and, unrepaired mtDNA damage has been frequently linked with several diseases. Exploration of mitochondrial perspective of diseases might lead to a better understanding of several diseases, and will certainly open new avenues for detection, cure, and prevention of ailments.
topic Genomics
Structure: Transcription & Translation
url http://f1000research.com/articles/4-176/v1
work_keys_str_mv AT gyaneshsingh mitochondrialdnadamageanddiseasesversion1referees1approved2approvedwithreservations
AT ucpachouri mitochondrialdnadamageanddiseasesversion1referees1approved2approvedwithreservations
AT devikachanukhaidem mitochondrialdnadamageanddiseasesversion1referees1approved2approvedwithreservations
AT amankundu mitochondrialdnadamageanddiseasesversion1referees1approved2approvedwithreservations
AT chiragchopra mitochondrialdnadamageanddiseasesversion1referees1approved2approvedwithreservations
AT pushplatasingh mitochondrialdnadamageanddiseasesversion1referees1approved2approvedwithreservations
_version_ 1724674130821775360

Similar Items