ADME, Metabolism Prediction and Hydrolysis Study of Melatonin Derivatives
Melatonin (MLT) is a well-known pineal hormone possessed with remarkable biological activities. However, its low oral bioavailability and high first-pass metabolism rate are important pharmacokinetics problems. Therefore, 5 MLT derivatives ( 1 - 5 ) were designed and synthesised in our group to solv...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-12-01
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| Series: | International Journal of Tryptophan Research |
| Online Access: | https://doi.org/10.1177/1178646920978245 |