Evaluation of Mango Byproduct Extracts as Antioxidant Against Pb-Acetate-Induced Oxidative Stress and Genotoxicity in Mice

The antioxidant and antiproliferative properties of mango by-products were investigated. This study was carried out to evaluate the protective role of mango peel or kernel defatted extracts against Pb-acetate adverse effects on oxidant/antioxidant status, liver dysfunction biomarkers, histopathologi...

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Main Authors: Makawy Aida I. El, Ashoush Ihab S., Abd-Elmoneim Omaima M.
Format: Article
Language:English
Published: Institute of Animal Reproduction and Food Research 2015-03-01
Series:Polish Journal of Food and Nutrition Sciences
Subjects:
Online Access:http://www.degruyter.com/view/j/pjfns.2015.65.issue-1/pjfns-2015-0009/pjfns-2015-0009.xml?format=INT
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spelling doaj-b8b9862e33424e5e820f803008f367102020-11-25T02:59:46ZengInstitute of Animal Reproduction and Food ResearchPolish Journal of Food and Nutrition Sciences2083-60072015-03-01651394710.1515/pjfns-2015-0009pjfns-2015-0009Evaluation of Mango Byproduct Extracts as Antioxidant Against Pb-Acetate-Induced Oxidative Stress and Genotoxicity in MiceMakawy Aida I. El0Ashoush Ihab S.1Abd-Elmoneim Omaima M.2Cell Biology Department, National Research Centre, El Buhouth Street, Dokki, Giza, EgyptFood Science Department, Faculty of Agriculture, Ain Shams University, Cairo, EgyptCell Biology Department, National Research Centre, El Buhouth Street, Dokki, Giza, EgyptThe antioxidant and antiproliferative properties of mango by-products were investigated. This study was carried out to evaluate the protective role of mango peel or kernel defatted extracts against Pb-acetate adverse effects on oxidant/antioxidant status, liver dysfunction biomarkers, histopathological changes and genotoxicity in male mice. Total phenolic content and antioxidant activity of both extracts were evaluated. Two doses of both extracts (50 and 100 mg/kg) were used to evaluate their role against the toxicity of Pb-acetate (500 ppm). Mice given mango extracts with Pb-acetate had significantly lower plasma MDA, AST and ALT and higher glutathione than mice given Pb-acetate alone. Mango extracts prevented the histopathological changes in liver induced by Pb-acetate and decreased the cytotoxicity of lead by increasing the ratio of PCE/NCE. Mango extract treatment reduced the DNA damage induced by Pb-acetate in liver as demonstrated by a reduction in micronuclei and decrease in tail length, tail DNA% and Olive tail moment. It can be concluded that mango by-product extracts have potential to protect from oxidative stress and genotoxicity of lead.http://www.degruyter.com/view/j/pjfns.2015.65.issue-1/pjfns-2015-0009/pjfns-2015-0009.xml?format=INTmango byproductslead acetateantioxidant activitiesoxidative stressliver dysfunctiongenotoxicity
collection DOAJ
language English
format Article
sources DOAJ
author Makawy Aida I. El
Ashoush Ihab S.
Abd-Elmoneim Omaima M.
spellingShingle Makawy Aida I. El
Ashoush Ihab S.
Abd-Elmoneim Omaima M.
Evaluation of Mango Byproduct Extracts as Antioxidant Against Pb-Acetate-Induced Oxidative Stress and Genotoxicity in Mice
Polish Journal of Food and Nutrition Sciences
mango byproducts
lead acetate
antioxidant activities
oxidative stress
liver dysfunction
genotoxicity
author_facet Makawy Aida I. El
Ashoush Ihab S.
Abd-Elmoneim Omaima M.
author_sort Makawy Aida I. El
title Evaluation of Mango Byproduct Extracts as Antioxidant Against Pb-Acetate-Induced Oxidative Stress and Genotoxicity in Mice
title_short Evaluation of Mango Byproduct Extracts as Antioxidant Against Pb-Acetate-Induced Oxidative Stress and Genotoxicity in Mice
title_full Evaluation of Mango Byproduct Extracts as Antioxidant Against Pb-Acetate-Induced Oxidative Stress and Genotoxicity in Mice
title_fullStr Evaluation of Mango Byproduct Extracts as Antioxidant Against Pb-Acetate-Induced Oxidative Stress and Genotoxicity in Mice
title_full_unstemmed Evaluation of Mango Byproduct Extracts as Antioxidant Against Pb-Acetate-Induced Oxidative Stress and Genotoxicity in Mice
title_sort evaluation of mango byproduct extracts as antioxidant against pb-acetate-induced oxidative stress and genotoxicity in mice
publisher Institute of Animal Reproduction and Food Research
series Polish Journal of Food and Nutrition Sciences
issn 2083-6007
publishDate 2015-03-01
description The antioxidant and antiproliferative properties of mango by-products were investigated. This study was carried out to evaluate the protective role of mango peel or kernel defatted extracts against Pb-acetate adverse effects on oxidant/antioxidant status, liver dysfunction biomarkers, histopathological changes and genotoxicity in male mice. Total phenolic content and antioxidant activity of both extracts were evaluated. Two doses of both extracts (50 and 100 mg/kg) were used to evaluate their role against the toxicity of Pb-acetate (500 ppm). Mice given mango extracts with Pb-acetate had significantly lower plasma MDA, AST and ALT and higher glutathione than mice given Pb-acetate alone. Mango extracts prevented the histopathological changes in liver induced by Pb-acetate and decreased the cytotoxicity of lead by increasing the ratio of PCE/NCE. Mango extract treatment reduced the DNA damage induced by Pb-acetate in liver as demonstrated by a reduction in micronuclei and decrease in tail length, tail DNA% and Olive tail moment. It can be concluded that mango by-product extracts have potential to protect from oxidative stress and genotoxicity of lead.
topic mango byproducts
lead acetate
antioxidant activities
oxidative stress
liver dysfunction
genotoxicity
url http://www.degruyter.com/view/j/pjfns.2015.65.issue-1/pjfns-2015-0009/pjfns-2015-0009.xml?format=INT
work_keys_str_mv AT makawyaidaiel evaluationofmangobyproductextractsasantioxidantagainstpbacetateinducedoxidativestressandgenotoxicityinmice
AT ashoushihabs evaluationofmangobyproductextractsasantioxidantagainstpbacetateinducedoxidativestressandgenotoxicityinmice
AT abdelmoneimomaimam evaluationofmangobyproductextractsasantioxidantagainstpbacetateinducedoxidativestressandgenotoxicityinmice
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