Different Gene Mutation Spectrum of the Paired CSF and Plasma Samples in Lung Adenocarcinoma with Leptomeningeal Metastases: the Liquid Biopsy Based on Circulating Tumor DNA

Different Gene Mutation Spectrum of the Paired CSF and Plasma Samples in Lung Adenocarcinoma with Leptomeningeal Metastases: the Liquid Biopsy Based on Circulating Tumor DNA

Background and objective Leptomeningeal metastasis (LM) are a severe complication of non-small cell lung cancer (NSCLC), and normally accompanied by poor prognosis. For the patients with targetable mutations, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are the preferred t...

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Bibliographic Details
Main Authors: Huiying LI, Yu XIE, Yongjuan LIN, Tingting YU, Zhenyu YIN
Format: Article
Language:zho
Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2020-08-01
Series:Chinese Journal of Lung Cancer
Subjects:
lung neoplasms
leptomeningeal metastases
cerebrospinal fluid
circulating tumor dna
next generation sequencing
Online Access:http://dx.doi.org/10.3779/j.issn.1009-3419.2020.102.14

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