Prenatal endotoxemia and placental drug transport in the mouse: placental size-specific effects.

Prenatal endotoxemia and placental drug transport in the mouse: placental size-specific effects.

Lipopolysaccharide (LPS) in high doses inhibits placental multidrug resistance P-glycoprotein (P-gp--Abcb1a/b) and breast cancer resistance protein (BCRP--Abcg2). This potentially impairs fetal protection against harmful factors in the maternal circulation. However, it is unknown whether LPS exposur...

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Bibliographic Details
Main Authors: Enrrico Bloise, Manzerul Bhuiyan, Melanie C Audette, Sophie Petropoulos, Mohsen Javam, William Gibb, Stephen G Matthews
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3677882?pdf=render

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