Effect of Autologous Platelet Rich Fibrin on the Healing of Experimental Articular Cartilage Defects of the Knee in an Animal Model

The effect of autologous platelet rich fibrin (PRF), a second generation platelet product, on the healing of experimental articular cartilage lesions was evaluated in an animal model. Full thickness cartilage lesions with a diameter of 6 mm and depth of 5 mm were created in the weight bearing area o...

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Main Authors:	Davoud Kazemi, Ashraf Fakhrjou, Vahid Mirzazadeh Dizaji, Majid Khanzadeh Alishahi
Format:	Article
Language:	English
Published:	Hindawi Limited 2014-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2014/486436

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spelling	doaj-b88bfc7cd8fa47e39514d7219361c6f82020-11-24T23:51:15ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/486436486436Effect of Autologous Platelet Rich Fibrin on the Healing of Experimental Articular Cartilage Defects of the Knee in an Animal ModelDavoud Kazemi0Ashraf Fakhrjou1Vahid Mirzazadeh Dizaji2Majid Khanzadeh Alishahi3Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, IranDepartment of Pathology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranCollege of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, IranCollege of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, IranThe effect of autologous platelet rich fibrin (PRF), a second generation platelet product, on the healing of experimental articular cartilage lesions was evaluated in an animal model. Full thickness cartilage lesions with a diameter of 6 mm and depth of 5 mm were created in the weight bearing area of femoral condyles of both hind limbs in 12 adult mixed breed dogs. Defects in the left hind limb of each dog were repaired by PRF implantation whereas those in the right hind limb were left empty. The animals were euthanized at 4, 16, and 24 weeks following surgery and the resultant repair tissue was investigated macroscopically and microscopically. The results of macroscopic and histological evaluations indicated that there were significant differences between the PRF treated and untreated defects. In conclusion, the present study indicated that the use of platelet rich fibrin as a source of autologous growth factors leads to improvement in articular cartilage repair.http://dx.doi.org/10.1155/2014/486436
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Davoud Kazemi Ashraf Fakhrjou Vahid Mirzazadeh Dizaji Majid Khanzadeh Alishahi
spellingShingle	Davoud Kazemi Ashraf Fakhrjou Vahid Mirzazadeh Dizaji Majid Khanzadeh Alishahi Effect of Autologous Platelet Rich Fibrin on the Healing of Experimental Articular Cartilage Defects of the Knee in an Animal Model BioMed Research International
author_facet	Davoud Kazemi Ashraf Fakhrjou Vahid Mirzazadeh Dizaji Majid Khanzadeh Alishahi
author_sort	Davoud Kazemi
title	Effect of Autologous Platelet Rich Fibrin on the Healing of Experimental Articular Cartilage Defects of the Knee in an Animal Model
title_short	Effect of Autologous Platelet Rich Fibrin on the Healing of Experimental Articular Cartilage Defects of the Knee in an Animal Model
title_full	Effect of Autologous Platelet Rich Fibrin on the Healing of Experimental Articular Cartilage Defects of the Knee in an Animal Model
title_fullStr	Effect of Autologous Platelet Rich Fibrin on the Healing of Experimental Articular Cartilage Defects of the Knee in an Animal Model
title_full_unstemmed	Effect of Autologous Platelet Rich Fibrin on the Healing of Experimental Articular Cartilage Defects of the Knee in an Animal Model
title_sort	effect of autologous platelet rich fibrin on the healing of experimental articular cartilage defects of the knee in an animal model
publisher	Hindawi Limited
series	BioMed Research International
issn	2314-6133 2314-6141
publishDate	2014-01-01
description	The effect of autologous platelet rich fibrin (PRF), a second generation platelet product, on the healing of experimental articular cartilage lesions was evaluated in an animal model. Full thickness cartilage lesions with a diameter of 6 mm and depth of 5 mm were created in the weight bearing area of femoral condyles of both hind limbs in 12 adult mixed breed dogs. Defects in the left hind limb of each dog were repaired by PRF implantation whereas those in the right hind limb were left empty. The animals were euthanized at 4, 16, and 24 weeks following surgery and the resultant repair tissue was investigated macroscopically and microscopically. The results of macroscopic and histological evaluations indicated that there were significant differences between the PRF treated and untreated defects. In conclusion, the present study indicated that the use of platelet rich fibrin as a source of autologous growth factors leads to improvement in articular cartilage repair.
url	http://dx.doi.org/10.1155/2014/486436
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Effect of Autologous Platelet Rich Fibrin on the Healing of Experimental Articular Cartilage Defects of the Knee in an Animal Model

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