The Effects of Sodium Dichloroacetate on Mitochondrial Dysfunction and Neuronal Death Following Hypoglycemia-Induced Injury

The Effects of Sodium Dichloroacetate on Mitochondrial Dysfunction and Neuronal Death Following Hypoglycemia-Induced Injury

Our previous studies demonstrated that some degree of neuronal death is caused by hypoglycemia, but a subsequent and more severe wave of neuronal cell death occurs due to glucose reperfusion, which results from the rapid restoration of low blood glucose levels. Mitochondrial dysfunction caused by hy...

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Bibliographic Details
Main Authors: A Ra Kho, Bo Young Choi, Song Hee Lee, Dae Ki Hong, Jeong Hyun Jeong, Beom Seok Kang, Dong Hyeon Kang, Kyoung-Ha Park, Jae Bong Park, Sang Won Suh
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cells
Subjects:
hypoglycemia
sodium dichloroacetate
pyruvate dehydrogenase kinase
pyruvate dehydrogenase
oxidative stress
neuron death
Online Access:https://www.mdpi.com/2073-4409/8/5/405

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