Polymer-Encapsulated PC12 Cells: Long-Term Survival and Associated Reduction in Lesion-Induced Rotational Behavior

Intrastriatal implantation of a dopaminergic cell line surrounded by a permeable, thermoplastic membrane was investigated as a method of long-term dopamine (DA) delivery within the central nervous system (CNS). An increase in DA release from PC12 cell-loaded capsules maintained in vitro was associat...

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Bibliographic Details
Main Authors: Patrick A. Tresco, Shelley R. Winn, Sanda Tan, Christine B. Jaeger, Lloyd A. Greene, Patrick Aebischer
Format: Article
Language:English
Published: SAGE Publishing 1992-03-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/0963689792001002-307