Angiotensin II upregulates RANKL/NFATC1 expression in synovial cells from patients with rheumatoid arthritis through the ERK1/2 and JNK pathways

Angiotensin II upregulates RANKL/NFATC1 expression in synovial cells from patients with rheumatoid arthritis through the ERK1/2 and JNK pathways

Abstract Background Angiotensin II (Ang II) is associated with rheumatoid arthritis (RA) development. The present study investigated the impact of Ang II on the expression of receptor activator of nuclear factor-κB ligand (RANKL), as well as of nuclear factor of activated T cells cytoplasmic 1 (NFAT...

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Bibliographic Details
Main Authors: Zhiping Zhao, Yongtao Zhang, Changyao Wang, Xiangyu Wang, Yingzhen Wang, Haining Zhang
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Angiotensin II
RANKL
NFATC1
Synovial cells
ERK1/2
JNK pathways
Online Access:https://doi.org/10.1186/s13018-021-02451-0

Internet

https://doi.org/10.1186/s13018-021-02451-0

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