Role of genetic and environmental factors in DNA methylation of lipid metabolism

A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate genetic variants and environmental factors int...

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Main Authors:	Zhen He, Rong Zhang, Feng Jiang, Wenjing Hou, Cheng Hu
Format:	Article
Language:	English
Published:	Elsevier 2018-03-01
Series:	Genes and Diseases
Subjects:	DNA methylation Environmental exposure Gene expression Genetic variations Lipid metabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352304217300867

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spelling	doaj-b87f0cb4341845b6a488e829debea9ae2020-11-25T01:08:30ZengElsevierGenes and Diseases2352-30422018-03-015191510.1016/j.gendis.2017.11.005Role of genetic and environmental factors in DNA methylation of lipid metabolismZhen He0Rong Zhang1Feng Jiang2Wenjing Hou3Cheng Hu4Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaFengxian Central Hospital, Affiliated to Southern Medical University, 6600 Nanfeng Road, Shanghai, 201499, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaA number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate genetic variants and environmental factors into phenotypic traits. Therefore, elucidating the factors that underlie inter-individual DNA methylation variations gives us an opportunity to predict diseases and interfere with the establishment of aberrant DNA methylation early. In this review, we summarize the findings of DNA methylation-related studies focused on unravelling the potential role of genetic and environmental factors in DNA methylation and the regulatory effect of DNA methylation on gene expression in lipid metabolism.http://www.sciencedirect.com/science/article/pii/S2352304217300867DNA methylationEnvironmental exposureGene expressionGenetic variationsLipid metabolism
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zhen He Rong Zhang Feng Jiang Wenjing Hou Cheng Hu
spellingShingle	Zhen He Rong Zhang Feng Jiang Wenjing Hou Cheng Hu Role of genetic and environmental factors in DNA methylation of lipid metabolism Genes and Diseases DNA methylation Environmental exposure Gene expression Genetic variations Lipid metabolism
author_facet	Zhen He Rong Zhang Feng Jiang Wenjing Hou Cheng Hu
author_sort	Zhen He
title	Role of genetic and environmental factors in DNA methylation of lipid metabolism
title_short	Role of genetic and environmental factors in DNA methylation of lipid metabolism
title_full	Role of genetic and environmental factors in DNA methylation of lipid metabolism
title_fullStr	Role of genetic and environmental factors in DNA methylation of lipid metabolism
title_full_unstemmed	Role of genetic and environmental factors in DNA methylation of lipid metabolism
title_sort	role of genetic and environmental factors in dna methylation of lipid metabolism
publisher	Elsevier
series	Genes and Diseases
issn	2352-3042
publishDate	2018-03-01
description	A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate genetic variants and environmental factors into phenotypic traits. Therefore, elucidating the factors that underlie inter-individual DNA methylation variations gives us an opportunity to predict diseases and interfere with the establishment of aberrant DNA methylation early. In this review, we summarize the findings of DNA methylation-related studies focused on unravelling the potential role of genetic and environmental factors in DNA methylation and the regulatory effect of DNA methylation on gene expression in lipid metabolism.
topic	DNA methylation Environmental exposure Gene expression Genetic variations Lipid metabolism
url	http://www.sciencedirect.com/science/article/pii/S2352304217300867
work_keys_str_mv	AT zhenhe roleofgeneticandenvironmentalfactorsindnamethylationoflipidmetabolism AT rongzhang roleofgeneticandenvironmentalfactorsindnamethylationoflipidmetabolism AT fengjiang roleofgeneticandenvironmentalfactorsindnamethylationoflipidmetabolism AT wenjinghou roleofgeneticandenvironmentalfactorsindnamethylationoflipidmetabolism AT chenghu roleofgeneticandenvironmentalfactorsindnamethylationoflipidmetabolism
_version_	1725182275895689216

Role of genetic and environmental factors in DNA methylation of lipid metabolism

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