Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia.

Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia.

The hypoxic microenvironment of glioblastoma multiforme (GBM) is thought to increase resistance to cancer therapies. Recent evidence suggests that hypoxia induces protein phosphatase 2A (PP2A), a regulator of cell cycle and cell death. The effects of PP2A on GBM tumor cell proliferation and survival...

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Bibliographic Details
Main Authors: Christoph P Hofstetter, Jan-Karl Burkhardt, Benjamin J Shin, Demirkan B Gürsel, Lynn Mubita, Ramana Gorrepati, Cameron Brennan, Eric C Holland, John A Boockvar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3256196?pdf=render

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http://europepmc.org/articles/PMC3256196?pdf=render

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