Selective inhibition of human translation termination by a drug-like compound

The drug-like compound PF846 and its derivatives inhibit the translation of specific mRNAs by the human ribosome. Here the authors show how PF846 arrests translation at the stop codon by slowing hydrolysis of the protein nascent chain at the ribosome P-site tRNA by eukaryotic release factor 1 (eRF1)...

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Main Authors:	Wenfei Li, Stacey Tsai-Lan Chang, Fred. R. Ward, Jamie H. D. Cate
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18765-2

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spelling	doaj-b86e399a4ec045d89db7d9e3ea9c2b222021-10-03T11:51:47ZengNature Publishing GroupNature Communications2041-17232020-10-011111910.1038/s41467-020-18765-2Selective inhibition of human translation termination by a drug-like compoundWenfei Li0Stacey Tsai-Lan Chang1Fred. R. Ward2Jamie H. D. Cate3Department of Molecular & Cell Biology, University of CaliforniaDepartment of Molecular & Cell Biology, University of CaliforniaDepartment of Molecular & Cell Biology, University of CaliforniaDepartment of Molecular & Cell Biology, University of CaliforniaThe drug-like compound PF846 and its derivatives inhibit the translation of specific mRNAs by the human ribosome. Here the authors show how PF846 arrests translation at the stop codon by slowing hydrolysis of the protein nascent chain at the ribosome P-site tRNA by eukaryotic release factor 1 (eRF1).https://doi.org/10.1038/s41467-020-18765-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wenfei Li Stacey Tsai-Lan Chang Fred. R. Ward Jamie H. D. Cate
spellingShingle	Wenfei Li Stacey Tsai-Lan Chang Fred. R. Ward Jamie H. D. Cate Selective inhibition of human translation termination by a drug-like compound Nature Communications
author_facet	Wenfei Li Stacey Tsai-Lan Chang Fred. R. Ward Jamie H. D. Cate
author_sort	Wenfei Li
title	Selective inhibition of human translation termination by a drug-like compound
title_short	Selective inhibition of human translation termination by a drug-like compound
title_full	Selective inhibition of human translation termination by a drug-like compound
title_fullStr	Selective inhibition of human translation termination by a drug-like compound
title_full_unstemmed	Selective inhibition of human translation termination by a drug-like compound
title_sort	selective inhibition of human translation termination by a drug-like compound
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	The drug-like compound PF846 and its derivatives inhibit the translation of specific mRNAs by the human ribosome. Here the authors show how PF846 arrests translation at the stop codon by slowing hydrolysis of the protein nascent chain at the ribosome P-site tRNA by eukaryotic release factor 1 (eRF1).
url	https://doi.org/10.1038/s41467-020-18765-2
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Selective inhibition of human translation termination by a drug-like compound

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