Grape seed extract ameliorates PhIP-induced colonic injury by modulating gut microbiota, lipid metabolism, and NF-κB signaling pathway in rats

Grape seed extract ameliorates PhIP-induced colonic injury by modulating gut microbiota, lipid metabolism, and NF-κB signaling pathway in rats

2-Amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) is a common carcinogen produced in thermally processed protein-rich foods. This study explored the protective effects of grape seed extract (GSE) against colonic injury induced by short-term exposure to PhIP and the underlying mechanisms involv...

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Bibliographic Details
Main Authors: Xiuli Zhao, Yuekun Wu, Hengchao Liu, Nan Hu, Yan Zhang, Shuo Wang
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Journal of Functional Foods
Subjects:
PhIP
Colonic injury
Grape seed extract
Intestinal flora
Lipid metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621000116

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http://www.sciencedirect.com/science/article/pii/S1756464621000116

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