Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administrat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.649395/full |
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DOAJ |
| language |
English |
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Article |
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DOAJ |
| author |
Javad Sharifi-Rad Cristina Quispe Zhazira Mukazhanova Ewa Knut Aknur Turgumbayeva Aknur Turgumbayeva Aliya Kipchakbayeva Gulnaz Seitimova Mohamad Fawzi Mahomoodally Devina Lobine Aaron Koay Jinfan Wang Helen Sheridan Gerardo Leyva-Gómez María L. Del Prado-Audelo Hernán Cortes Antonio Rescigno Paolo Zucca Oksana Sytar Oksana Sytar Muhammad Imran Célia F. Rodrigues Natália Cruz-Martins Natália Cruz-Martins Natália Cruz-Martins Halina Ekiert Manoj Kumar Ahmad Faizal Abdull Razis Ahmad Faizal Abdull Razis Usman Sunusi Usman Sunusi Ramla Muhammad Kamal Ramla Muhammad Kamal Agnieszka Szopa |
| spellingShingle |
Javad Sharifi-Rad Cristina Quispe Zhazira Mukazhanova Ewa Knut Aknur Turgumbayeva Aknur Turgumbayeva Aliya Kipchakbayeva Gulnaz Seitimova Mohamad Fawzi Mahomoodally Devina Lobine Aaron Koay Jinfan Wang Helen Sheridan Gerardo Leyva-Gómez María L. Del Prado-Audelo Hernán Cortes Antonio Rescigno Paolo Zucca Oksana Sytar Oksana Sytar Muhammad Imran Célia F. Rodrigues Natália Cruz-Martins Natália Cruz-Martins Natália Cruz-Martins Halina Ekiert Manoj Kumar Ahmad Faizal Abdull Razis Ahmad Faizal Abdull Razis Usman Sunusi Usman Sunusi Ramla Muhammad Kamal Ramla Muhammad Kamal Agnieszka Szopa Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer Frontiers in Molecular Biosciences resveratrol cancer therapy drug-delivery systems clinical applications bio-availability |
| author_facet |
Javad Sharifi-Rad Cristina Quispe Zhazira Mukazhanova Ewa Knut Aknur Turgumbayeva Aknur Turgumbayeva Aliya Kipchakbayeva Gulnaz Seitimova Mohamad Fawzi Mahomoodally Devina Lobine Aaron Koay Jinfan Wang Helen Sheridan Gerardo Leyva-Gómez María L. Del Prado-Audelo Hernán Cortes Antonio Rescigno Paolo Zucca Oksana Sytar Oksana Sytar Muhammad Imran Célia F. Rodrigues Natália Cruz-Martins Natália Cruz-Martins Natália Cruz-Martins Halina Ekiert Manoj Kumar Ahmad Faizal Abdull Razis Ahmad Faizal Abdull Razis Usman Sunusi Usman Sunusi Ramla Muhammad Kamal Ramla Muhammad Kamal Agnieszka Szopa |
| author_sort |
Javad Sharifi-Rad |
| title |
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
| title_short |
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
| title_full |
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
| title_fullStr |
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
| title_full_unstemmed |
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer |
| title_sort |
resveratrol-based nanoformulations as an emerging therapeutic strategy for cancer |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Molecular Biosciences |
| issn |
2296-889X |
| publishDate |
2021-09-01 |
| description |
Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed. |
| topic |
resveratrol cancer therapy drug-delivery systems clinical applications bio-availability |
| url |
https://www.frontiersin.org/articles/10.3389/fmolb.2021.649395/full |
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doaj-b8665312a4744f1da13bd00f253497602021-09-04T01:00:25ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-09-01810.3389/fmolb.2021.649395649395Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for CancerJavad Sharifi-Rad0Cristina Quispe1Zhazira Mukazhanova2Ewa Knut3Aknur Turgumbayeva4Aknur Turgumbayeva5Aliya Kipchakbayeva6Gulnaz Seitimova7Mohamad Fawzi Mahomoodally8Devina Lobine9Aaron Koay10Jinfan Wang11Helen Sheridan12Gerardo Leyva-Gómez13María L. Del Prado-Audelo14Hernán Cortes15Antonio Rescigno16Paolo Zucca17Oksana Sytar18Oksana Sytar19Muhammad Imran20Célia F. Rodrigues21Natália Cruz-Martins22Natália Cruz-Martins23Natália Cruz-Martins24Halina Ekiert25Manoj Kumar26Ahmad Faizal Abdull Razis27Ahmad Faizal Abdull Razis28Usman Sunusi29Usman Sunusi30Ramla Muhammad Kamal31Ramla Muhammad Kamal32Agnieszka Szopa33Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranFacultad de Ciencias de la Salud, Universidad Arturo Prat, Iquique, ChileDepartment of Natural Sciences and Technologies, Sarsen Amanzholov East Kazakhstan State University, Ust-Kamenogorsk, KazakhstanChair and Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, PolandAsfendiyarov Kazakh National Medical University, School Pharmacy, Almaty, KazakhstanAl-Farabi Kazakh National University, Higher School of Medicine, Almaty, KazakhstanFaculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, KazakhstanFaculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, KazakhstanDepartment of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, MauritiusDepartment of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, MauritiusTrinity College Dublin, NatPro (Natural Products Research Centre), School of Pharmacy and Pharmaceutical Science, Dublin, IrelandTrinity College Dublin, NatPro (Natural Products Research Centre), School of Pharmacy and Pharmaceutical Science, Dublin, IrelandTrinity College Dublin, NatPro (Natural Products Research Centre), School of Pharmacy and Pharmaceutical Science, Dublin, Ireland0Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico City, Mexico0Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico City, Mexico1Laboratorio de Medicina Genómica, Departamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, Mexico City, Mexico2Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, Cagliari, Italy2Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, Cagliari, Italy3Department of Plant Biology, Institute of Biology, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine4Department of Plant Physiology, Slovak University of Agriculture, Nitra, Slovakia5University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan6Laboratory for Process Engineering, Environment, Biotechnology and Energy—Department of Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal7Faculty of Medicine, University of Porto, Porto, Portugal8Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal9Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, PortugalChair and Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland0Chemical and Biochemical Processing Division, ICAR – Central Institute for Research on Cotton Technology, Mumbai, India1Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia2Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia2Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia3Department of Biochemistry, Bayero University Kano, Kano, Nigeria2Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia4Department of Pharmacology, Federal University Dutse, Dutse, NigeriaChair and Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, PolandResveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.https://www.frontiersin.org/articles/10.3389/fmolb.2021.649395/fullresveratrolcancer therapydrug-delivery systemsclinical applicationsbio-availability |