Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools

Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools

System lupus erythematosus (SLE) is a multifactorial systemic autoimmune disease with a wide variety of presenting features. SLE is believed to result from dysregulated immune responses, loss of tolerance of CD4 T cells and B cells to ubiquitous self-antigens, and the subsequent production of anti-n...

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Main Authors: Jared Klarquist, Zhenyuan Zhou, Nan Shen, Edith M. Janssen
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2016/5045248
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spelling doaj-b865d0acb9014500af9e61795070f7772020-11-24T22:32:39ZengHindawi LimitedMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/50452485045248Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic ToolsJared Klarquist0Zhenyuan Zhou1Nan Shen2Edith M. Janssen3Division of Immunobiology, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USAShanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDivision of Immunobiology, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USASystem lupus erythematosus (SLE) is a multifactorial systemic autoimmune disease with a wide variety of presenting features. SLE is believed to result from dysregulated immune responses, loss of tolerance of CD4 T cells and B cells to ubiquitous self-antigens, and the subsequent production of anti-nuclear and other autoreactive antibodies. Recent research has associated lupus development with changes in the dendritic cell (DC) compartment, including altered DC subset frequency and localization, overactivation of mDCs and pDCs, and functional defects in DCs. Here we discuss the current knowledge on the role of DC dysfunction in SLE pathogenesis, with the focus on DCs as targets for interventional therapies.http://dx.doi.org/10.1155/2016/5045248
collection DOAJ
language English
format Article
sources DOAJ
author Jared Klarquist
Zhenyuan Zhou
Nan Shen
Edith M. Janssen
spellingShingle Jared Klarquist
Zhenyuan Zhou
Nan Shen
Edith M. Janssen
Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools
Mediators of Inflammation
author_facet Jared Klarquist
Zhenyuan Zhou
Nan Shen
Edith M. Janssen
author_sort Jared Klarquist
title Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools
title_short Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools
title_full Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools
title_fullStr Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools
title_full_unstemmed Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools
title_sort dendritic cells in systemic lupus erythematosus: from pathogenic players to therapeutic tools
publisher Hindawi Limited
series Mediators of Inflammation
issn 0962-9351
1466-1861
publishDate 2016-01-01
description System lupus erythematosus (SLE) is a multifactorial systemic autoimmune disease with a wide variety of presenting features. SLE is believed to result from dysregulated immune responses, loss of tolerance of CD4 T cells and B cells to ubiquitous self-antigens, and the subsequent production of anti-nuclear and other autoreactive antibodies. Recent research has associated lupus development with changes in the dendritic cell (DC) compartment, including altered DC subset frequency and localization, overactivation of mDCs and pDCs, and functional defects in DCs. Here we discuss the current knowledge on the role of DC dysfunction in SLE pathogenesis, with the focus on DCs as targets for interventional therapies.
url http://dx.doi.org/10.1155/2016/5045248
work_keys_str_mv AT jaredklarquist dendriticcellsinsystemiclupuserythematosusfrompathogenicplayerstotherapeutictools
AT zhenyuanzhou dendriticcellsinsystemiclupuserythematosusfrompathogenicplayerstotherapeutictools
AT nanshen dendriticcellsinsystemiclupuserythematosusfrompathogenicplayerstotherapeutictools
AT edithmjanssen dendriticcellsinsystemiclupuserythematosusfrompathogenicplayerstotherapeutictools
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