Design, Synthesis and Biological Evaluation of Jahanyne Analogs as Cell Cycle Arrest Inducers

Design, Synthesis and Biological Evaluation of Jahanyne Analogs as Cell Cycle Arrest Inducers

Jahanyne, a lipopeptide with a unique terminal alkynyl and OEP (2-(1-oxo-ethyl)-pyrrolidine) moiety, exhibits anticancer activity. We synthesized jahanyne and analogs modified at the OEP moiety, employing an α-fluoromethyl ketone (FMK) strategy. Preliminary bioassays indicated that compound...

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Bibliographic Details
Main Authors: Baijun Ye, Jianmiao Gong, Qiuying Li, Shiqi Bao, Xuemei Zhang, Jing Chen, Qing Meng, Bolin Chen, Peng Jiang, Liang Wang, Yue Chen
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Marine Drugs
Subjects:
jahanyne
α-fluoromethyl ketone
lipopeptide
g0/g1 phase arrest
Online Access:https://www.mdpi.com/1660-3397/18/3/176

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