Molecular subtypes and clinicopathological features of breastcancer
Breast cancer is a heterogeneous disease with regard to morphological spectrum, clinical presentation and response to therapy. Based on immunohistochemistry detection of estrogen receptor, progesterone receptor, Her-2 status, proliferation rate and clusters of basal gene expression, breast cancers c...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2013-04-01
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| Series: | Journal of the Medical Sciences |
| Online Access: | https://jurnal.ugm.ac.id/bik/article/view/3376 |
| Summary: | Breast cancer is a heterogeneous disease with regard to morphological spectrum, clinical presentation and response to therapy. Based on immunohistochemistry detection of estrogen receptor, progesterone receptor, Her-2 status, proliferation rate and clusters of basal gene expression, breast cancers can be classified into luminal A, luminal B, basal-like/triple negative, and Her-2 positive. It was suggested that there was a close relationship between molecular subtypes and clinicopathological features of breast cancer, as they are very important to predict prognosis and therapeutic implications.
Keywords: molecular subtypes - breast cancer- clinicopathological features -heterogeneity –theraputicimplications |
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| ISSN: | 0126-1312 2356-3931 |