Lattice complex assembled by noncompetitive anti-EGFR antibodies regulates actin cytoskeletal reorganization

Lattice complex assembled by noncompetitive anti-EGFR antibodies regulates actin cytoskeletal reorganization

Abstract Background Recent evidence of clinical trials highlights that the combination of two noncompetitive anti-EGFR antibodies can benefit patients with several cancers. Previous studies propose that a lattice complex assembled by antibodies and EGFR down-regulates surface EGFR by rapid internali...

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Bibliographic Details
Main Authors: Dianshuai Huang, Tianqi Lu, Xingyu Du, Xi Xi, Xin Zhang, Xitian Zhang, Haoran Zhang, Fei Sun
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Cancer Cell International
Subjects:
EGFR
Lattice complex
Noncompetitive antibody combination
Cytoskeleton
PIP2
Online Access:http://link.springer.com/article/10.1186/s12935-020-01204-z

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http://link.springer.com/article/10.1186/s12935-020-01204-z

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