Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells

Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells

Fatty acid synthase, a key enzyme of de novo lipogenesis, is an attractive therapeutic target in cancer. The novel fatty acid synthase inhibitor, TVB-3664, shows anti-cancer activity in multiple cancers including colorectal cancer; however, it is unclear whether uptake of exogeneous fatty acids can...

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Bibliographic Details
Main Authors: James Drury, Piotr G. Rychahou, Daheng He, Naser Jafari, Chi Wang, Eun Y. Lee, Heidi L. Weiss, Bernard Mark Evers, Yekaterina Y. Zaytseva
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
lipogenesis
anticancer activity
FASN-targeted therapy
fatty acid metabolism
TVB inhibitors
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01185/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01185/full

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