Significant Post-Chemotherapy Decrease of Ovarian Reserve in Iranian Women With Breast Cancer

• Main Authors: Bita Eslami, Amirmohsen Jalaeefar, Ashraf Moini, Ramesh Omranipour, Maryam Haghighi, Sadaf Alipour
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2020-11-01
• Series: Acta Medica Iranica
• Subjects: Breast cancer; anti-mullerian hormone; Ovarian reserve; Chemotherapy
• Online Access: https://acta.tums.ac.ir/index.php/acta/article/view/8337

Fertility preservation counseling has a high priority in young breast cancer (BC) patients. Cytotoxic chemicals used for chemotherapy in these patients increased the risk of premature ovarian failure. This study evaluated the anti-mullerian hormone (AMH) level at the time of diagnosis and within a month after the end of chemotherapy, while predicting the time of the return of ovarian function in BC cases (n=46) younger than 46 years for the first time in Iran. Cases were selected from those attending the breast oncology clinic of the two hospitals with a newly diagnosed in situ or invasive BC. The present study results showed AMH levels were significantly decreased in almost all women within a month after chemotherapy. It seems that the need for fertility preservation depends on patient age and baseline AMH level, but counseling should be offered by the clinician in young breast cancer patients.