Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage

Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage

Radiation damage assessment of the small intestine is important in nuclear accidents or routine radiotherapy of abdominal tumors. This article reviews the clinical symptoms and molecular mechanisms of radiation-induced small intestinal damage and summarizes recent research on biomarkers of such dama...

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Main Authors: Fei Ye, Jing Ning, Zeenath Fardous, Takanori Katsube, Qiang Li, Bing Wang
Format: Article
Language:English
Published: SAGE Publishing 2020-09-01
Series:Dose-Response
Online Access:https://doi.org/10.1177/1559325820962341
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spelling doaj-b82b38a97c3440c6aaa61470e92152042020-11-25T03:52:48ZengSAGE PublishingDose-Response1559-32582020-09-011810.1177/1559325820962341Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine DamageFei Ye0Jing Ning1Zeenath Fardous2Takanori Katsube3Qiang Li4Bing Wang5 , Chinese Academy of Sciences, Lanzhou, People’s Republic of China , Lanzhou, People’s Republic of China , Atomic Energy Research Establishment, Bangladesh Atomic Energy Commission, Dhaka, Bangladesh , Chiba, Japan , Chinese Academy of Sciences, Lanzhou, People’s Republic of China , Chiba, JapanRadiation damage assessment of the small intestine is important in nuclear accidents or routine radiotherapy of abdominal tumors. This article reviews the clinical symptoms and molecular mechanisms of radiation-induced small intestinal damage and summarizes recent research on biomarkers of such damage. Citrulline is the most promising biomarker for the evaluation of radiation-induced small intestinal damage caused by radiotherapy and nuclear accidents. This article also summarizes the factors influencing plasma citrulline measurement investigated in the latest research, as well as new findings on the concentration of citrulline in saliva and urine after different types of radiation.https://doi.org/10.1177/1559325820962341
collection DOAJ
language English
format Article
sources DOAJ
author Fei Ye
Jing Ning
Zeenath Fardous
Takanori Katsube
Qiang Li
Bing Wang
spellingShingle Fei Ye
Jing Ning
Zeenath Fardous
Takanori Katsube
Qiang Li
Bing Wang
Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage
Dose-Response
author_facet Fei Ye
Jing Ning
Zeenath Fardous
Takanori Katsube
Qiang Li
Bing Wang
author_sort Fei Ye
title Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage
title_short Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage
title_full Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage
title_fullStr Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage
title_full_unstemmed Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage
title_sort citrulline, a potential biomarker of radiation-induced small intestine damage
publisher SAGE Publishing
series Dose-Response
issn 1559-3258
publishDate 2020-09-01
description Radiation damage assessment of the small intestine is important in nuclear accidents or routine radiotherapy of abdominal tumors. This article reviews the clinical symptoms and molecular mechanisms of radiation-induced small intestinal damage and summarizes recent research on biomarkers of such damage. Citrulline is the most promising biomarker for the evaluation of radiation-induced small intestinal damage caused by radiotherapy and nuclear accidents. This article also summarizes the factors influencing plasma citrulline measurement investigated in the latest research, as well as new findings on the concentration of citrulline in saliva and urine after different types of radiation.
url https://doi.org/10.1177/1559325820962341
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AT zeenathfardous citrullineapotentialbiomarkerofradiationinducedsmallintestinedamage
AT takanorikatsube citrullineapotentialbiomarkerofradiationinducedsmallintestinedamage
AT qiangli citrullineapotentialbiomarkerofradiationinducedsmallintestinedamage
AT bingwang citrullineapotentialbiomarkerofradiationinducedsmallintestinedamage
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