Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics.

Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics.

No therapeutics or vaccines currently exist for human coronaviruses (HCoVs). The Severe Acute Respiratory Syndrome-associated coronavirus (SARS-CoV) epidemic in 2002-2003, and the recent emergence of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in April 2012, emphasize the high probabilit...

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Bibliographic Details
Main Authors: Everett Clinton Smith, Hervé Blanc, Matthew C Surdel, Marco Vignuzzi, Mark R Denison
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3744431?pdf=render

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