Colorectal Cancer Blood-Based Biomarkers

Colorectal Cancer Blood-Based Biomarkers

Mortality and morbidity associated with colorectal cancer (CRC) are increasing globally, partly due to lack of early detection of the disease. The screening is usually performed with colonoscopy, which is invasive and unpleasant, discouraging participation in the screening. As a source of noninvasiv...

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Main Authors: Nina Hauptman, Damjan Glavač
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Gastroenterology Research and Practice
Online Access:http://dx.doi.org/10.1155/2017/2195361
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spelling doaj-b8270b49e50a4925a8083e1697810bd62020-11-24T22:31:25ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/21953612195361Colorectal Cancer Blood-Based BiomarkersNina Hauptman0Damjan Glavač1Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaDepartment of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaMortality and morbidity associated with colorectal cancer (CRC) are increasing globally, partly due to lack of early detection of the disease. The screening is usually performed with colonoscopy, which is invasive and unpleasant, discouraging participation in the screening. As a source of noninvasive and easily accessible biomarkers, liquid biopsies are emerging. Blood-based biomarkers have the potential as diagnostic and prognostic tool in CRC. Early stage detection of CRC with high sensitivity and specificity would likely lead to higher participation in the screening test. It would also improve the prognosis of the disease and improve the recurrence risk. In this review, we summarize the potential biomarkers for early detection and monitoring of CRC.http://dx.doi.org/10.1155/2017/2195361
collection DOAJ
language English
format Article
sources DOAJ
author Nina Hauptman
Damjan Glavač
spellingShingle Nina Hauptman
Damjan Glavač
Colorectal Cancer Blood-Based Biomarkers
Gastroenterology Research and Practice
author_facet Nina Hauptman
Damjan Glavač
author_sort Nina Hauptman
title Colorectal Cancer Blood-Based Biomarkers
title_short Colorectal Cancer Blood-Based Biomarkers
title_full Colorectal Cancer Blood-Based Biomarkers
title_fullStr Colorectal Cancer Blood-Based Biomarkers
title_full_unstemmed Colorectal Cancer Blood-Based Biomarkers
title_sort colorectal cancer blood-based biomarkers
publisher Hindawi Limited
series Gastroenterology Research and Practice
issn 1687-6121
1687-630X
publishDate 2017-01-01
description Mortality and morbidity associated with colorectal cancer (CRC) are increasing globally, partly due to lack of early detection of the disease. The screening is usually performed with colonoscopy, which is invasive and unpleasant, discouraging participation in the screening. As a source of noninvasive and easily accessible biomarkers, liquid biopsies are emerging. Blood-based biomarkers have the potential as diagnostic and prognostic tool in CRC. Early stage detection of CRC with high sensitivity and specificity would likely lead to higher participation in the screening test. It would also improve the prognosis of the disease and improve the recurrence risk. In this review, we summarize the potential biomarkers for early detection and monitoring of CRC.
url http://dx.doi.org/10.1155/2017/2195361
work_keys_str_mv AT ninahauptman colorectalcancerbloodbasedbiomarkers
AT damjanglavac colorectalcancerbloodbasedbiomarkers
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