Copper exposure induces hepatic G0/G1 cell-cycle arrest through suppressing the Ras/PI3K/Akt signaling pathway in mice

Copper exposure induces hepatic G0/G1 cell-cycle arrest through suppressing the Ras/PI3K/Akt signaling pathway in mice

Copper (Cu), as a common chemical contaminant in environment, is known to be toxic at high concentrations. The current research demonstrates the effects of copper upon hepatocyte cell-cycle progression (CCP) in mice. Institute of cancer research (ICR) mice (n = 240) at an age of four weeks were divi...

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Bibliographic Details
Main Authors: Huan Liu, Huidan Deng, Zhijie Jian, Hengmin Cui, Hongrui Guo, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao, Yanqiu Zhu
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Copper
G0/G1 cell-cycle arrest
Ras/PI3K/Akt signaling pathway
Liver
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321006308

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http://www.sciencedirect.com/science/article/pii/S0147651321006308

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