Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG inhibition sensitizes cells to ionizing radiation an...
Full description
Bibliographic Details
| Main Authors: |
Jerry H. Houl,
Zu Ye,
Chris A. Brosey,
Lakshitha P. F. Balapiti-Modarage,
Sarita Namjoshi,
Albino Bacolla,
Daniel Laverty,
Brian L. Walker,
Yasin Pourfarjam,
Leslie S. Warden,
Naga Babu Chinnam,
Davide Moiani,
Roderick A. Stegeman,
Mei-Kuang Chen,
Mien-Chie Hung,
Zachary D. Nagel,
Tom Ellenberger,
In-Kwon Kim,
Darin E. Jones,
Zamal Ahmed,
John A. Tainer |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Publishing Group
2019-12-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-019-13508-4
|
|---|
