Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20
De novo lipogenesis is tightly controlled by hormonal and nutritional signals and plays an important role in energy homoeostasis. Here, Liu et al. show that zinc finger protein ZBTB20 regulates the expression of key glycolytic and lipogenic genes by modulating ChREBP expression and transcriptional a...
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Nature Publishing Group
2017-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14824 |
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doaj-b81cc4076fdc4b64ab9d4bbb686418802021-05-11T07:38:51ZengNature Publishing GroupNature Communications2041-17232017-03-018111310.1038/ncomms14824Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20Gan Liu0Luting Zhou1Hai Zhang2Rong Chen3Ye Zhang4Ling Li5Jun-Yu Lu6Hui Jiang7Dong Liu8Shasha Qi9Ying-Ming Jiang10Kai Yin11Zhifang Xie12Yuguang Shi13Yong Liu14Xuetao Cao15Yu-Xia Chen16Dajin Zou17Weiping J. Zhang18Department of Pathophysiology, Second Military Medical UniversityDepartment of Pathophysiology, Second Military Medical UniversityDepartment of Pathophysiology, Second Military Medical UniversityDepartment of Pathophysiology, Second Military Medical UniversityDepartment of Pathophysiology, Second Military Medical UniversityDepartment of Pathophysiology, Second Military Medical UniversityDepartment of Pathophysiology, Second Military Medical UniversityDepartment of Pathophysiology, Second Military Medical UniversityDepartment of Pathophysiology, Second Military Medical UniversityDepartment of Pathophysiology, Second Military Medical UniversityNational Key Laboratory of Medical Immunology, Second Military Medical UniversityObesity & Diabetes Research Center, Second Military Medical UniversityDepartment of Pathophysiology, Second Military Medical UniversityBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San AntonioInstitute of Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of ScienceNational Key Laboratory of Medical Immunology, Second Military Medical UniversityDepartment of Pathophysiology, Second Military Medical UniversityObesity & Diabetes Research Center, Second Military Medical UniversityDepartment of Pathophysiology, Second Military Medical UniversityDe novo lipogenesis is tightly controlled by hormonal and nutritional signals and plays an important role in energy homoeostasis. Here, Liu et al. show that zinc finger protein ZBTB20 regulates the expression of key glycolytic and lipogenic genes by modulating ChREBP expression and transcriptional activity.https://doi.org/10.1038/ncomms14824 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Gan Liu Luting Zhou Hai Zhang Rong Chen Ye Zhang Ling Li Jun-Yu Lu Hui Jiang Dong Liu Shasha Qi Ying-Ming Jiang Kai Yin Zhifang Xie Yuguang Shi Yong Liu Xuetao Cao Yu-Xia Chen Dajin Zou Weiping J. Zhang |
| spellingShingle |
Gan Liu Luting Zhou Hai Zhang Rong Chen Ye Zhang Ling Li Jun-Yu Lu Hui Jiang Dong Liu Shasha Qi Ying-Ming Jiang Kai Yin Zhifang Xie Yuguang Shi Yong Liu Xuetao Cao Yu-Xia Chen Dajin Zou Weiping J. Zhang Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20 Nature Communications |
| author_facet |
Gan Liu Luting Zhou Hai Zhang Rong Chen Ye Zhang Ling Li Jun-Yu Lu Hui Jiang Dong Liu Shasha Qi Ying-Ming Jiang Kai Yin Zhifang Xie Yuguang Shi Yong Liu Xuetao Cao Yu-Xia Chen Dajin Zou Weiping J. Zhang |
| author_sort |
Gan Liu |
| title |
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20 |
| title_short |
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20 |
| title_full |
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20 |
| title_fullStr |
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20 |
| title_full_unstemmed |
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20 |
| title_sort |
regulation of hepatic lipogenesis by the zinc finger protein zbtb20 |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-03-01 |
| description |
De novo lipogenesis is tightly controlled by hormonal and nutritional signals and plays an important role in energy homoeostasis. Here, Liu et al. show that zinc finger protein ZBTB20 regulates the expression of key glycolytic and lipogenic genes by modulating ChREBP expression and transcriptional activity. |
| url |
https://doi.org/10.1038/ncomms14824 |
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