Effects of a reactive oxygen species generator, napabucasin (BBI608), on tolerability, safety, pharmacokinetics, and QT/QTc interval in healthy volunteers

Effects of a reactive oxygen species generator, napabucasin (BBI608), on tolerability, safety, pharmacokinetics, and QT/QTc interval in healthy volunteers

Abstract This study examined the safety, tolerability, and pharmacokinetics (PK) of napabucasin in healthy Asian and non‐Asian participants and investigated the potential for QT/QTc interval prolongation. This five‐part (A–E) study proceeded in a stepwise manner, unless stopping criteria were met. P...

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Bibliographic Details
Main Authors: Naoto Noda, Takeshi Takagaki, Yasuhide Yodo, Yuzo Horibuchi, Shuichi Iino, Shunji Matsuki, Yoichiro Ogama, Hiroyoshi Kakuyama
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Pharmacology Research & Perspectives
Subjects:
Asian
healthy volunteers
napabucasin
non‐Asian
pharmacokinetics
QT/QTc interval
Online Access:https://doi.org/10.1002/prp2.874

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