A Topical Formulation of Melatoninergic Compounds Exerts Strong Hypotensive and Neuroprotective Effects in a Rat Model of Hypertensive Glaucoma

A Topical Formulation of Melatoninergic Compounds Exerts Strong Hypotensive and Neuroprotective Effects in a Rat Model of Hypertensive Glaucoma

Melatonin is of great importance for regulating several eye processes, including pressure homeostasis. Melatonin in combination with agomelatine has been recently reported to reduce intraocular pressure (IOP) with higher efficacy than each compound alone. Here, we used the methylcellulose (MCE) rat...

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Bibliographic Details
Main Authors: Massimo Dal Monte, Maurizio Cammalleri, Rosario Amato, Salvatore Pezzino, Roberta Corsaro, Paola Bagnoli, Dario Rusciano
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
intraocular pressure
timolol
brimonidine
melatonin/agomelatine
electroretinography
retinal ganglion cells
Online Access:https://www.mdpi.com/1422-0067/21/23/9267

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