Heritable multiplex genetic engineering in rats using CRISPR/Cas9.

Heritable multiplex genetic engineering in rats using CRISPR/Cas9.

The CRISPR/Cas9 system has been proven to be an efficient gene-editing tool for genome modification of cells and organisms. Multiplex genetic engineering in rat holds a bright future for the study of complex disease. Here, we show that this system enables the simultaneous disruption of four genes (A...

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Bibliographic Details
Main Authors: Yuanwu Ma, Bin Shen, Xu Zhang, Yingdong Lu, Wei Chen, Jing Ma, Xingxu Huang, Lianfeng Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3943732?pdf=render

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