Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating

Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating

<p>Abstract</p> <p>Triplet repeats contribute to normal variation in behavioral traits and when expanded, cause brain disorders. While Huntington's Disease is known to be caused by a CAG triplet repeat in the gene Huntingtin, the effect of CAG repeats on brain function below d...

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Main Authors: Wassink Tom, Epping Eric A, Nopoulos Peg, Schlaggar Bradley L, Perlmutter Joel
Format: Article
Language:English
Published: BMC 2011-10-01
Series:Behavioral and Brain Functions
Online Access:http://www.behavioralandbrainfunctions.com/content/7/1/45
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spelling doaj-b7ee2e6813c9447082fdd325b0d307ea2020-11-24T22:20:15ZengBMCBehavioral and Brain Functions1744-90812011-10-01714510.1186/1744-9081-7-45Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative matingWassink TomEpping Eric ANopoulos PegSchlaggar Bradley LPerlmutter Joel<p>Abstract</p> <p>Triplet repeats contribute to normal variation in behavioral traits and when expanded, cause brain disorders. While Huntington's Disease is known to be caused by a CAG triplet repeat in the gene Huntingtin, the effect of CAG repeats on brain function below disease threshold has not been studied. The current study shows a significant correlation between the CAG repeat length of the maternal and paternal allele in the Huntingtin gene among healthy subjects, suggesting assortative mating.</p> http://www.behavioralandbrainfunctions.com/content/7/1/45
collection DOAJ
language English
format Article
sources DOAJ
author Wassink Tom
Epping Eric A
Nopoulos Peg
Schlaggar Bradley L
Perlmutter Joel
spellingShingle Wassink Tom
Epping Eric A
Nopoulos Peg
Schlaggar Bradley L
Perlmutter Joel
Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
Behavioral and Brain Functions
author_facet Wassink Tom
Epping Eric A
Nopoulos Peg
Schlaggar Bradley L
Perlmutter Joel
author_sort Wassink Tom
title Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
title_short Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
title_full Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
title_fullStr Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
title_full_unstemmed Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
title_sort correlation of cag repeat length between the maternal and paternal allele of the huntingtin gene: evidence for assortative mating
publisher BMC
series Behavioral and Brain Functions
issn 1744-9081
publishDate 2011-10-01
description <p>Abstract</p> <p>Triplet repeats contribute to normal variation in behavioral traits and when expanded, cause brain disorders. While Huntington's Disease is known to be caused by a CAG triplet repeat in the gene Huntingtin, the effect of CAG repeats on brain function below disease threshold has not been studied. The current study shows a significant correlation between the CAG repeat length of the maternal and paternal allele in the Huntingtin gene among healthy subjects, suggesting assortative mating.</p>
url http://www.behavioralandbrainfunctions.com/content/7/1/45
work_keys_str_mv AT wassinktom correlationofcagrepeatlengthbetweenthematernalandpaternalalleleofthehuntingtingeneevidenceforassortativemating
AT eppingerica correlationofcagrepeatlengthbetweenthematernalandpaternalalleleofthehuntingtingeneevidenceforassortativemating
AT nopoulospeg correlationofcagrepeatlengthbetweenthematernalandpaternalalleleofthehuntingtingeneevidenceforassortativemating
AT schlaggarbradleyl correlationofcagrepeatlengthbetweenthematernalandpaternalalleleofthehuntingtingeneevidenceforassortativemating
AT perlmutterjoel correlationofcagrepeatlengthbetweenthematernalandpaternalalleleofthehuntingtingeneevidenceforassortativemating
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