PTBP3 contributes to colorectal cancer growth and metastasis via translational activation of HIF-1α

PTBP3 contributes to colorectal cancer growth and metastasis via translational activation of HIF-1α

Abstract Background Colorectal cancer (CRC) remains the fourth most common cause of cancer-related mortality worldwide. We aimed to identify key molecules and signalling pathways mediating CRC growth and metastasis. Polypyrimidine tract-binding protein 3 (PTBP3) is a member of PTB family. A prooncog...

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Bibliographic Details
Main Authors: Pingfu Hou, Fang Chen, Hongmei Yong, Tian Lin, Jingjing Li, Yu Pan, Tao Jiang, Minle Li, Yansu Chen, Jun Song, Junnian Zheng, Jin Bai
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
PTBP3
Colorectal cancer
HIF-1α
Protein translation
Tumor metastasis
Online Access:http://link.springer.com/article/10.1186/s13046-019-1312-y

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http://link.springer.com/article/10.1186/s13046-019-1312-y

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