The Deconstructed Granuloma: A Complex High-Throughput Drug Screening Platform for the Discovery of Host-Directed Therapeutics Against Tuberculosis

The Deconstructed Granuloma: A Complex High-Throughput Drug Screening Platform for the Discovery of Host-Directed Therapeutics Against Tuberculosis

Mycobacterium tuberculosis (Mtb) continues to be a threat to Global Public Health, and its control will require an array of therapeutic strategies. It has been appreciated that high-throughput screens using cell-based assays to identify compounds targeting Mtb within macrophages represent a valuable...

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Bibliographic Details
Main Authors: Lu Huang, Nicole L. Kushner, Monique E. Theriault, Davide Pisu, Shumin Tan, Case W. McNamara, H. Mike Petrassi, David G. Russell, Amanda C. Brown
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
tuberculosis
pulmonary
Mycobacterium tuberculosis
high-throughput screening assays
host-directed therapeutics
macrophages
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00275/full

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