The Pyridone-Annelated Isoindigo (5‘-Cl) Induces Apoptosis, Dysregulation of Mitochondria and Formation of ROS in Leukemic HL-60 Cells

The Pyridone-Annelated Isoindigo (5‘-Cl) Induces Apoptosis, Dysregulation of Mitochondria and Formation of ROS in Leukemic HL-60 Cells

Background/Aims: In our quest to develop an isoindigo with improved efficacy and bioavailability, we recently synthesized a series of novel substituted pyridone-annelated isoindigo and evaluated their antiproliferative effects. We identified the compound [(E)-1-(5'-Chloro-2'-oxoindolin-3&#...

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Bibliographic Details
Main Authors: Ayman M. Saleh, Ahmad Aljada, Mustafa M. El-Abadelah, Salim S. Sabri, Jalal A. Zahra, Amre Nasr, Mohammad A. Aziz
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Reactive oxygen species (ROS)
Bcl-2
Mitochondria dysfunction
Pyridone-annelated isoindigo
Bax
Phosphorylation of Bcl-2
HL-60 cells
Anticancer compound
Apoptosis
Online Access:http://www.karger.com/Article/FullText/374004

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http://www.karger.com/Article/FullText/374004

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