Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors
Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implicated in major depressive disorder.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11876-5 |
| id |
doaj-b7ca995a09f14264a865413198bdb889 |
|---|---|
| record_format |
Article |
| spelling |
doaj-b7ca995a09f14264a865413198bdb8892021-05-11T11:47:30ZengNature Publishing GroupNature Communications2041-17232019-09-0110111410.1038/s41467-019-11876-5Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviorsNataliya Gorinski0Monika Bijata1Sonal Prasad2Alexander Wirth3Dalia Abdel Galil4Andre Zeug5Daria Bazovkina6Elena Kondaurova7Elizabeth Kulikova8Tatiana Ilchibaeva9Monika Zareba-Koziol10Francesco Papaleo11Diego Scheggia12Gaga Kochlamazashvili13Alexander Dityatev14Ian Smyth15Adam Krzystyniak16Jakub Wlodarczyk17Diethelm W. Richter18Tatyana Strekalova19Stephan Sigrist20Claudia Bang21Lisa Hobuß22Jan Fiedler23Thomas Thum24Vladimir S. Naumenko25Ghanshyam Pandey26Evgeni Ponimaskin27Cellular Neurophysiology, Hannover Medical SchoolCellular Neurophysiology, Hannover Medical SchoolCellular Neurophysiology, Hannover Medical SchoolCellular Neurophysiology, Hannover Medical SchoolCellular Neurophysiology, Hannover Medical SchoolCellular Neurophysiology, Hannover Medical SchoolBehavioural Neurogenomics, Institute of Cytology and GeneticsBehavioural Neurogenomics, Institute of Cytology and GeneticsBehavioural Neurogenomics, Institute of Cytology and GeneticsBehavioural Neurogenomics, Institute of Cytology and GeneticsCell Biophysics, Nencki InstituteNeuroscience and Brain Technologies, Istituto Italiano di TecnologiaNeuroscience and Brain Technologies, Istituto Italiano di TecnologiaNeuroscience and Brain Technologies, Istituto Italiano di TecnologiaNeuroscience and Brain Technologies, Istituto Italiano di TecnologiaAnatomy & Developmental Biology, Monash UniversityCell Biophysics, Nencki InstituteCell Biophysics, Nencki InstituteNeuro and Sensory Physiology, University of GöttingenSechenov First Moscow State Medical UniversityInstitute of Biology, Free University BerlinInstitute of Molecular and Translational Therapeutic Strategies, Hannover Medical SchoolInstitute of Molecular and Translational Therapeutic Strategies, Hannover Medical SchoolInstitute of Molecular and Translational Therapeutic Strategies, Hannover Medical SchoolInstitute of Molecular and Translational Therapeutic Strategies, Hannover Medical SchoolBehavioural Neurogenomics, Institute of Cytology and GeneticsDepartment of Psychiatry, University of IllinoisCellular Neurophysiology, Hannover Medical SchoolPalmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implicated in major depressive disorder.https://doi.org/10.1038/s41467-019-11876-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Nataliya Gorinski Monika Bijata Sonal Prasad Alexander Wirth Dalia Abdel Galil Andre Zeug Daria Bazovkina Elena Kondaurova Elizabeth Kulikova Tatiana Ilchibaeva Monika Zareba-Koziol Francesco Papaleo Diego Scheggia Gaga Kochlamazashvili Alexander Dityatev Ian Smyth Adam Krzystyniak Jakub Wlodarczyk Diethelm W. Richter Tatyana Strekalova Stephan Sigrist Claudia Bang Lisa Hobuß Jan Fiedler Thomas Thum Vladimir S. Naumenko Ghanshyam Pandey Evgeni Ponimaskin |
| spellingShingle |
Nataliya Gorinski Monika Bijata Sonal Prasad Alexander Wirth Dalia Abdel Galil Andre Zeug Daria Bazovkina Elena Kondaurova Elizabeth Kulikova Tatiana Ilchibaeva Monika Zareba-Koziol Francesco Papaleo Diego Scheggia Gaga Kochlamazashvili Alexander Dityatev Ian Smyth Adam Krzystyniak Jakub Wlodarczyk Diethelm W. Richter Tatyana Strekalova Stephan Sigrist Claudia Bang Lisa Hobuß Jan Fiedler Thomas Thum Vladimir S. Naumenko Ghanshyam Pandey Evgeni Ponimaskin Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors Nature Communications |
| author_facet |
Nataliya Gorinski Monika Bijata Sonal Prasad Alexander Wirth Dalia Abdel Galil Andre Zeug Daria Bazovkina Elena Kondaurova Elizabeth Kulikova Tatiana Ilchibaeva Monika Zareba-Koziol Francesco Papaleo Diego Scheggia Gaga Kochlamazashvili Alexander Dityatev Ian Smyth Adam Krzystyniak Jakub Wlodarczyk Diethelm W. Richter Tatyana Strekalova Stephan Sigrist Claudia Bang Lisa Hobuß Jan Fiedler Thomas Thum Vladimir S. Naumenko Ghanshyam Pandey Evgeni Ponimaskin |
| author_sort |
Nataliya Gorinski |
| title |
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors |
| title_short |
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors |
| title_full |
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors |
| title_fullStr |
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors |
| title_full_unstemmed |
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors |
| title_sort |
attenuated palmitoylation of serotonin receptor 5-ht1a affects receptor function and contributes to depression-like behaviors |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-09-01 |
| description |
Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implicated in major depressive disorder. |
| url |
https://doi.org/10.1038/s41467-019-11876-5 |
| work_keys_str_mv |
AT nataliyagorinski attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT monikabijata attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT sonalprasad attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT alexanderwirth attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT daliaabdelgalil attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT andrezeug attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT dariabazovkina attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT elenakondaurova attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT elizabethkulikova attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT tatianailchibaeva attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT monikazarebakoziol attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT francescopapaleo attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT diegoscheggia attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT gagakochlamazashvili attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT alexanderdityatev attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT iansmyth attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT adamkrzystyniak attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT jakubwlodarczyk attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT diethelmwrichter attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT tatyanastrekalova attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT stephansigrist attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT claudiabang attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT lisahobuß attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT janfiedler attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT thomasthum attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT vladimirsnaumenko attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT ghanshyampandey attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors AT evgeniponimaskin attenuatedpalmitoylationofserotoninreceptor5ht1aaffectsreceptorfunctionandcontributestodepressionlikebehaviors |
| _version_ |
1721445993048702976 |