Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity

Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity

High-fat diet (HFD) and inflammation are the key contributors to insulin resistance and type 2 diabetes (T2D). Previous study shows fatty acid-induced accumulation of damaged, reactive oxygen species (ROS)-generating mitochondria, and this in turn activates the NLRP3 inflammasome interference with...

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Bibliographic Details
Main Authors: Sijun Yang, Chunxiang Xia, Shali Li, Leilei Du, Lu Zhang, Ronbin Zhou
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Mitophagy
Proinflammatory response
Rheb
KIF5B
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714000548

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http://www.sciencedirect.com/science/article/pii/S2213231714000548

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