Mitochondria in precision medicine; linking bioenergetics and metabolomics in platelets

Mitochondria in precision medicine; linking bioenergetics and metabolomics in platelets

Mitochondria possess reserve bioenergetic capacity, supporting protection and resilience in the face of disease. Approaches are limited to understand factors that impact mitochondrial functional reserve in humans. We applied the mitochondrial stress test (MST) to platelets from healthy subjects and...

Full description

Bibliographic Details
Main Authors:	Balu K. Chacko, Matthew R. Smith, Michelle S. Johnson, Gloria Benavides, Matilda L. Culp, Jyotsna Pilli, Sruti Shiva, Karan Uppal, Young-Mi Go, Dean P. Jones, Victor M. Darley-Usmar
Format:	Article
Language:	English
Published:	Elsevier 2019-04-01
Series:	Redox Biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231719302034

Similar Items

A precision medicine approach to defining the impact of doxorubicin on the bioenergetic-metabolite interactome in human platelets
by: Matthew Ryan Smith, et al.
Published: (2020-01-01)

A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers
by: Philip A. Kramer, et al.
Published: (2014-01-01)

Feasibility of cellular bioenergetics as a biomarker in porphyria patients
by: Balu Chacko, et al.
Published: (2019-06-01)

Mitochondrially targeted compounds and their impact on cellular bioenergetics
by: Colin Reily, et al.
Published: (2013-01-01)

The Bioenergetic Health Index is a sensitive measure of oxidative stress in human monocytes
by: Balu K. Chacko, et al.
Published: (2016-08-01)

Alterations in platelet bioenergetics in Group 2 PH-HFpEF patients.
by: Quyen L Nguyen, et al.
Published: (2019-01-01)

Monocyte bioenergetic function is associated with body composition in virologically suppressed HIV-infected women
by: Amanda L. Willig, et al.
Published: (2017-08-01)

Metabolic plasticity in resting and thrombin activated platelets.
by: Saranya Ravi, et al.
Published: (2015-01-01)

Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death.
by: Samantha Giordano, et al.
Published: (2012-01-01)

Integrated computational model of the bioenergetics of isolated lung mitochondria.
by: Xiao Zhang, et al.
Published: (2018-01-01)

Age-dependent changes in intervertebral disc cell mitochondria and bioenergetics
by: R Hartman, et al.
Published: (2018-10-01)

Mitochondria, Bioenergetics and Excitotoxicity: New Therapeutic Targets in Perinatal Brain Injury
by: Bryan Leaw, et al.
Published: (2017-07-01)

Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons
by: Matthew Redmann, et al.
Published: (2017-04-01)

Response to Martin and colleagues: mitochondria do not boost the bioenergetic capacity of eukaryotic cells
by: Michael Lynch, et al.
Published: (2018-11-01)

Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing <it>Caenorhabditis elegans</it>
by: Vanfleteren Jacques R, et al.
Published: (2010-06-01)

The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS
by: Elena Obrador, et al.
Published: (2021-06-01)

Endothelial cell and platelet bioenergetics: effect of glucose and nutrient composition.
by: Brian D Fink, et al.
Published: (2012-01-01)

Untargeted metabolomics reveal dysregulations in sugar, methionine, and tyrosine pathways in the prodromal state of AD
by: Ihab Hajjar, et al.
Published: (2020-01-01)

Mitochondria Biogenesis and Bioenergetics Gene Profiles in Isogenic Prostate Cells with Different Malignant Phenotypes
by: Tanya C. Burch, et al.
Published: (2016-01-01)

The Double-Edged Sword in Pathogenic Trypanosomatids: The Pivotal Role of Mitochondria in Oxidative Stress and Bioenergetics
by: Rubem Figueiredo Sadok Menna-Barreto, et al.
Published: (2014-01-01)

The Anticancer Agent Elesclomol Has Direct Effects on Mitochondrial Bioenergetic Function in Isolated Mammalian Mitochondria
by: Josephine S. Modica-Napolitano, et al.
Published: (2019-07-01)

Mycobacterial Control of Host Mitochondria: Bioenergetic and Metabolic Changes Shaping Cell Fate and Infection Outcome
by: Krishnaveni Mohareer, et al.
Published: (2020-09-01)

Influence of rare-earth based orthovanadate nanoparticles and cerium oxide on bioenergetic processes in mitochondria of hepatocytes
by: Е. А. Аверченко, et al.
Published: (2015-10-01)

The isolation and characterisation, by bioenergetic, biochemical and electron microscopic examination of mitochondria from whole skin tissue
by: Knight, A.
Published: (1978)

Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling
by: Luiz G. Gardinassi, et al.
Published: (2018-07-01)

Research on Precision Functional Medical Examination with Bioenergetic Device and Machine Learning
by: Hsien-Po Chiu, et al.
Published: (2018)

Inflammation/bioenergetics-associated neurodegenerative pathologies and concomitant diseases: a role of mitochondria targeted catalase and xanthophylls
by: Mikhail A Filippov, et al.
Published: (2021-01-01)

Mitochondria-associated lactate dehydrogenase is not a biologically significant contributor to bioenergetic function in murine striated muscle
by: Kyle L. Fulghum, et al.
Published: (2019-06-01)

Gentamicin Affects the Bioenergetics of Isolated Mitochondria and Collapses the Mitochondrial Membrane Potential in Cochlear Sensory Hair Cells
by: Molly O’Reilly, et al.
Published: (2019-09-01)

Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells
by: Kenneth P. Hough, et al.
Published: (2018-09-01)

Mitochondrial bioenergetics of metastatic breast cancer cells in response to dynamic changes in oxygen tension: effects of HIF-1α.
by: Anne R Diers, et al.
Published: (2013-01-01)

Serum Metabolomics Identifies Altered Bioenergetics, Signaling Cascades in Parallel with Exposome Markers in Crohn’s Disease
by: Yunjia Lai, et al.
Published: (2019-01-01)

Bioenergetics
Published: (2012)

Applications of Metabolomics to Precision Nutrition
by: Marcia LeVatte, et al.
Published: (2021-09-01)

Modeling of mitochondria bioenergetics using a composable chemiosmotic energy transduction rate law: theory and experimental validation.
by: Ivan Chang, et al.
Published: (2011-01-01)

Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics
by: Kelsey H. Fisher-Wellman, et al.
Published: (2019-02-01)

A comparison of the structure and function of eukaryotic C oxidases
by: Darley-Usmar, V. M.
Published: (1980)

A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure
by: Raymond J. Langley, et al.
Published: (2021-05-01)

Low‐intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults
by: Edgars Liepinsh, et al.
Published: (2020-06-01)

Bioenergetic analysis of ovarian cancer cell lines: profiling of histological subtypes and identification of a mitochondria-defective cell line.
by: Usawadee Dier, et al.
Published: (2014-01-01)