Paraneoplastic Stiff Person Syndrome in Early-Stage Breast Cancer with Positive Anti-Amphiphysin Antibodies

Paraneoplastic Stiff Person Syndrome in Early-Stage Breast Cancer with Positive Anti-Amphiphysin Antibodies

Stiff person syndrome (SPS) is a rare neurologic disorder, characterized by muscle rigidity and spasms. Anti-glutamic acid decarboxylase (anti-GAD) antibodies are associated with the classic form of SPS, while antibodies against amphiphysin are associated with the paraneoplastic form of the disease....

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Bibliographic Details
Main Authors: Vitalie Vacaras, Enia Eleonora Cucu, Roxana Radu, Dafin Fior Muresanu
Format: Article
Language:English
Published: Karger Publishers 2020-10-01
Series:Case Reports in Neurology
Subjects:
stiff person
cancer
anti-amphiphysin
Online Access:https://www.karger.com/Article/FullText/508942
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spelling doaj-b7b7273cb8dc48efae3334c1cc83bfcf2020-11-25T04:07:59ZengKarger PublishersCase Reports in Neurology1662-680X2020-10-0112333934710.1159/000508942508942Paraneoplastic Stiff Person Syndrome in Early-Stage Breast Cancer with Positive Anti-Amphiphysin AntibodiesVitalie VacarasEnia Eleonora CucuRoxana RaduDafin Fior MuresanuStiff person syndrome (SPS) is a rare neurologic disorder, characterized by muscle rigidity and spasms. Anti-glutamic acid decarboxylase (anti-GAD) antibodies are associated with the classic form of SPS, while antibodies against amphiphysin are associated with the paraneoplastic form of the disease. We present the case of a patient with paraneoplastic SPS, presenting with muscle cramps of lower extremities that progressed to severe muscle rigidity and spasms, associated with a right breast tumor and positive anti-amphiphysin antibodies. Paraneoplastic SPS is a rare neurological disorder, challenging for the physicians both to diagnose and treat.https://www.karger.com/Article/FullText/508942stiff personcanceranti-amphiphysin
collection DOAJ
language English
format Article
sources DOAJ
author Vitalie Vacaras
Enia Eleonora Cucu
Roxana Radu
Dafin Fior Muresanu
spellingShingle Vitalie Vacaras
Enia Eleonora Cucu
Roxana Radu
Dafin Fior Muresanu
Paraneoplastic Stiff Person Syndrome in Early-Stage Breast Cancer with Positive Anti-Amphiphysin Antibodies
Case Reports in Neurology
stiff person
cancer
anti-amphiphysin
author_facet Vitalie Vacaras
Enia Eleonora Cucu
Roxana Radu
Dafin Fior Muresanu
author_sort Vitalie Vacaras
title Paraneoplastic Stiff Person Syndrome in Early-Stage Breast Cancer with Positive Anti-Amphiphysin Antibodies
title_short Paraneoplastic Stiff Person Syndrome in Early-Stage Breast Cancer with Positive Anti-Amphiphysin Antibodies
title_full Paraneoplastic Stiff Person Syndrome in Early-Stage Breast Cancer with Positive Anti-Amphiphysin Antibodies
title_fullStr Paraneoplastic Stiff Person Syndrome in Early-Stage Breast Cancer with Positive Anti-Amphiphysin Antibodies
title_full_unstemmed Paraneoplastic Stiff Person Syndrome in Early-Stage Breast Cancer with Positive Anti-Amphiphysin Antibodies
title_sort paraneoplastic stiff person syndrome in early-stage breast cancer with positive anti-amphiphysin antibodies
publisher Karger Publishers
series Case Reports in Neurology
issn 1662-680X
publishDate 2020-10-01
description Stiff person syndrome (SPS) is a rare neurologic disorder, characterized by muscle rigidity and spasms. Anti-glutamic acid decarboxylase (anti-GAD) antibodies are associated with the classic form of SPS, while antibodies against amphiphysin are associated with the paraneoplastic form of the disease. We present the case of a patient with paraneoplastic SPS, presenting with muscle cramps of lower extremities that progressed to severe muscle rigidity and spasms, associated with a right breast tumor and positive anti-amphiphysin antibodies. Paraneoplastic SPS is a rare neurological disorder, challenging for the physicians both to diagnose and treat.
topic stiff person
cancer
anti-amphiphysin
url https://www.karger.com/Article/FullText/508942
work_keys_str_mv AT vitalievacaras paraneoplasticstiffpersonsyndromeinearlystagebreastcancerwithpositiveantiamphiphysinantibodies
AT eniaeleonoracucu paraneoplasticstiffpersonsyndromeinearlystagebreastcancerwithpositiveantiamphiphysinantibodies
AT roxanaradu paraneoplasticstiffpersonsyndromeinearlystagebreastcancerwithpositiveantiamphiphysinantibodies
AT dafinfiormuresanu paraneoplasticstiffpersonsyndromeinearlystagebreastcancerwithpositiveantiamphiphysinantibodies
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