Integrated Modeling of GC-Content, Mappability, Tumor Impurity and Aneuploidy for Accurate Detection of Genomic Aberrations

Integrated Modeling of GC-Content, Mappability, Tumor Impurity and Aneuploidy for Accurate Detection of Genomic Aberrations

Next-generation sequencing has been widely used in cancer-focused studies for comprehensive landscape of tumor genomes. Detection of genomic aberrations is one of the focal points in this area. Analysis of tumor sequencing data is usually complicated by several critical issues, such as GC-content bi...

Full description

Bibliographic Details
Main Authors: Zhenhua Yu, Ao Li, Liang Zou, Xuehong Sun, Minghui Wang, Peng Zhang
Format: Article
Language:English
Published: IEEE 2018-01-01
Series:IEEE Access
Subjects:
Hidden Markov model
next-generation sequencing
aberration detection
tumor impurity
aneuploidy
Online Access:https://ieeexplore.ieee.org/document/8502207/

Similar Items

Similar Items