Influence of Mesenchymal Stem Cell Transplantation in Retaining Ganglion Cell of End Stage Glaucoma Patients

• Main Author: Widya Artini
• Format: Article
• Language: English
• Published: Universitas Indonesia 2018-09-01
• Series: Journal Kedokteran Indonesia
• Subjects: stem cell; umbilical cord mesenchymal; end stage glaucoma; perg; gcipl.
• Online Access: http://journal.ui.ac.id/index.php/eJKI/article/view/9728
• ISSN: 2338-1426; 2338-6037

<p class="MsoNormal" style="text-align: justify;">Mesenchymal stem cells transplantation enhances nerve growth factor synthesis, brain derived nerve factor, glial cell line-derived neurotropic factor, and neurotrophin-3.. We report four end-stage primary open angle glaucoma patients, consisting of three males and one female with a median age of 68 years old, treated at RSCM on September 2017. Visual acuity ranged between 1/300 to 2/60 and intraocular pressure (IOP) between 10-14 mmHg. All patients underwent allogeneic mesenchymal stem cells transplantation derived from umbilical cord by subtenon injection and evaluated the results of the potential evoked retinograph and average thickness of ganglion cell-inner plexiform layer (GC-IPL). Three months later, two patients admitted their vision was improved. with, no significant anatomical structure changes were observed. 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