Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission
Drp1 and Dnm2 have been implicated in mitochondrial fission events, although their specific activities in constriction and scission have been unclear. Here, the authors demonstrate that Drp1 is sufficient to constrict and sever mitochondrial and peroxisomal membranes in the absence of Dnm proteins.
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07543-w |
| id |
doaj-b7aa83849104458696ba607a842a6b41 |
|---|---|
| record_format |
Article |
| spelling |
doaj-b7aa83849104458696ba607a842a6b412021-05-11T09:35:31ZengNature Publishing GroupNature Communications2041-17232018-12-019111510.1038/s41467-018-07543-wDynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fissionSukrut C. Kamerkar0Felix Kraus1Alice J. Sharpe2Thomas J. Pucadyil3Michael T. Ryan4Indian Institute of Science Education and ResearchDepartment of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash UniversityDepartment of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash UniversityIndian Institute of Science Education and ResearchDepartment of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash UniversityDrp1 and Dnm2 have been implicated in mitochondrial fission events, although their specific activities in constriction and scission have been unclear. Here, the authors demonstrate that Drp1 is sufficient to constrict and sever mitochondrial and peroxisomal membranes in the absence of Dnm proteins.https://doi.org/10.1038/s41467-018-07543-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sukrut C. Kamerkar Felix Kraus Alice J. Sharpe Thomas J. Pucadyil Michael T. Ryan |
| spellingShingle |
Sukrut C. Kamerkar Felix Kraus Alice J. Sharpe Thomas J. Pucadyil Michael T. Ryan Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission Nature Communications |
| author_facet |
Sukrut C. Kamerkar Felix Kraus Alice J. Sharpe Thomas J. Pucadyil Michael T. Ryan |
| author_sort |
Sukrut C. Kamerkar |
| title |
Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission |
| title_short |
Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission |
| title_full |
Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission |
| title_fullStr |
Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission |
| title_full_unstemmed |
Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission |
| title_sort |
dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-12-01 |
| description |
Drp1 and Dnm2 have been implicated in mitochondrial fission events, although their specific activities in constriction and scission have been unclear. Here, the authors demonstrate that Drp1 is sufficient to constrict and sever mitochondrial and peroxisomal membranes in the absence of Dnm proteins. |
| url |
https://doi.org/10.1038/s41467-018-07543-w |
| work_keys_str_mv |
AT sukrutckamerkar dynaminrelatedprotein1hasmembraneconstrictingandseveringabilitiessufficientformitochondrialandperoxisomalfission AT felixkraus dynaminrelatedprotein1hasmembraneconstrictingandseveringabilitiessufficientformitochondrialandperoxisomalfission AT alicejsharpe dynaminrelatedprotein1hasmembraneconstrictingandseveringabilitiessufficientformitochondrialandperoxisomalfission AT thomasjpucadyil dynaminrelatedprotein1hasmembraneconstrictingandseveringabilitiessufficientformitochondrialandperoxisomalfission AT michaeltryan dynaminrelatedprotein1hasmembraneconstrictingandseveringabilitiessufficientformitochondrialandperoxisomalfission |
| _version_ |
1721449564112683008 |