A Three-Compartment Pharmacokinetic Model to Predict the Interstitial Concentration of Talaporfin Sodium in the Myocardium for Photodynamic Therapy: A Method Combining Measured Fluorescence and Analysis of the Compartmental Origin of the Fluorescence

A Three-Compartment Pharmacokinetic Model to Predict the Interstitial Concentration of Talaporfin Sodium in the Myocardium for Photodynamic Therapy: A Method Combining Measured Fluorescence and Analysis of the Compartmental Origin of the Fluorescence

To evaluate the effectiveness of photodynamic therapy occurring in the interstitial space of the myocardium, we estimated the interstitial concentration of talaporfin sodium in the canine myocardium by constructing a three-compartment pharmacokinetic model based on measured changes in talaporfin sod...

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Bibliographic Details
Main Authors: Yuko Uno, Emiyu Ogawa, Eitaro Aiyoshi, Tsunenori Arai
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Bioengineering
Subjects:
talaporfin sodium
pharmacokinetics
three-compartment model
interstitial space
myocardial fluorescence
Online Access:http://www.mdpi.com/2306-5354/6/1/1

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