Histone Deacetylases Positively Regulate Transcription through the Elongation Machinery

Histone Deacetylases Positively Regulate Transcription through the Elongation Machinery

Transcription elongation regulates the expression of many genes, including oncogenes. Histone deacetylase (HDAC) inhibitors (HDACIs) block elongation, suggesting that HDACs are involved in gene activation. To understand this, we analyzed nascent transcription and elongation factor binding genome-wid...

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Bibliographic Details
Main Authors: Celeste B. Greer, Yoshiaki Tanaka, Yoon Jung Kim, Peng Xie, Michael Q. Zhang, In-Hyun Park, Tae Hoon Kim
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715011675

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