A Comparative Pathomorphological Findings Between Leiurus abdullahbayrami and Androctonus crassicauda (Scorpion: Buthidae) Envenomation in Rabbit Animal Model

• Main Authors: Ozcan Ozkan, Mehmet Eray Alcigir
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2019-04-01
• Series: Journal of Arthropod-Borne Diseases
• Subjects: Leirus abdullahbayrami; Androctonus crassicauda; Venom; Pathomorphology; Rabbit
• Online Access: https://jad.tums.ac.ir/index.php/jad/article/view/660

Background: The aim of study was to compare macroscopical and histopathological findings between venoms be-longing to two scorpion species, Androdoctonus crassicauda, and the newly discovered Leirus abdullahbayrami. Methods: The animals used in this experimental study were fifteen New Zealand bred rabbits. Three groups were constituted as group I (L. abdullahbayrami group, n= 6), group II (A. crassicauda group, n= 6) and group III (control group, n= 3). The animals in the L. abdullahbayrami group and the A. crassicauda group were envenomed through an intravenous route. The rabbits were monitored for the first 24h following the envenomation. The animals dead within that time period were examined and all animals were sacrificed and standard necropsy process was performed at 24h. Results: The pathomorphological findings from group I were found to be more severe than those observed in group II. The venom from the newly identified L. abdullahbayrami has a greater effect than the venom from the A. crassicauda. Moreover, as this was a rabbit modeling study, the L. abdullahbayrami might pose the most serious health threat to infants in particular due to their smaller body weight. Conclusion: These findings will provide a better understanding of envenomation of human beings in terms of the possible consequences of scorpion toxication on the organs.