The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells

<p>Abstract</p> <p>Background</p> <p>Regulator of chromosome condensation 1 (RCC1) is the guanine nucleotide exchange factor for Ran GTPase. Localised generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly and nu...

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Bibliographic Details
Main Authors: Sanderson Helen S, Hood Fiona E, Hitakomate Ekarat, Clarke Paul R
Format: Article
Language:English
Published: BMC 2010-06-01
Series:BMC Cell Biology
Online Access:http://www.biomedcentral.com/1471-2121/11/43

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