Single Institution Experience of Postoperative Electron Beam Radiation Therapy in the Treatment of Keloids

• Main Authors: Karthik S. Rishi, MD, DNB, Nivedita Sarkar, DMRT, Prashanta Kesari, MS, MRCS, DNB, MCh, Muddappa Pathikonda, MD, DMRT, Prakash Ramachandra, MRCP, FRCR, CCST, Pradeep Kumar Reddy Donapati, MD, G.V. Giri, MD, DMRT, DNB, B.S. Srinath, MS, FRCS(Glas), FRCS(Edin)
• Format: Article
• Language: English
• Published: Elsevier 2021-03-01
• Series: Advances in Radiation Oncology
• Online Access: http://www.sciencedirect.com/science/article/pii/S2452109420302980

Purpose: Surgical excision followed by postoperative radiation therapy is an accepted modality to prevent keloid recurrence. Our practice has been to use electron beam radiation postoperatively to prevent recurrence, and we share our experience with this method in this study. Methods and Materials: Twenty-two patients with 40 keloids treated postoperatively with electron beam radiation at our institution from 2014 to 2019 were analyzed retrospectively. Electron beam radiation was used for treatment in all cases, and radiation was initiated within 24 hours of surgery. A dose of 20 Gy in 5 fractions was delivered to the postoperative scar in 95% of the sites, and 8 Gy to 10 Gy in a single fraction was delivered to the remaining 5%. The patients were followed up, and recurrences were documented. Results: At a mean follow-up of 35 months (range, 7-66 months), local control and cosmesis were achieved in 90% (36 of 40) of the treated sites with electron beam radiation therapy delivered at a dose of 20 Gy in 5 fractions. All recurrent keloids were located on the anterior chest wall over the sternum. There was no difference in outcome based on age, sex, or keloid length. Conclusions: Electron beam radiation therapy is a feasible, convenient, and safe modality for postoperative treatment of keloids. It achieves excellent local control with no grade 3 or higher toxicities.